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Serum orexin-A levels are associated with disease progression and motor impairment in multiple sclerosis

  • Mehmet Gencer
  • Ece Akbayır
  • Melis Şen
  • Erdil Arsoy
  • Vuslat Yılmaz
  • Nesrin Bulut
  • Erdem TüzünEmail author
  • Recai Türkoğlu
Brief Communication
  • 69 Downloads

Abstract

Objective

Diencephalon is frequently affected in multiple sclerosis (MS), and lesions of this region are associated with increased disability. Orexin-A and melatonin, two foremost mediators of diencephalon, modulate cognitive and motor functions through several pathways including the brain-derived neurotrophic factor (BDNF)-cAMP response element-binding protein (CREB) signaling pathway. In this pilot study, our aim was to investigate the prognostic value of these factors in progression of cognitive and physical disability.

Methods

Levels of BDNF, melatonin, CREB, and orexin-A were determined by ELISA in sera of 25 relapsing remitting MS (RRMS) patients, 15 secondary progressive MS (SPMS) patients, and 20 healthy controls. Cognitive and motor functions were assessed by a neuropsychological test battery, timed 25-ft walk (T25-FW) and 9-hole peg (9-HP) tests.

Results

MS patients had significantly lower serum levels of orexin-A and BDNF than healthy controls, and SPMS patients had significantly lower levels of melatonin and orexin-A than RRMS patients. Serum orexin-A levels were negatively correlated with 9-HP, T25-FW test scores, and progression index in RRMS patients. BDNF, CREB, and melatonin levels did not show any significant correlation with clinical features including EDSS and cognitive/motor performance of the patients.

Conclusion

Our results suggest that orexin-A levels are decreased in parallel to disease progression and motor system deterioration in the earlier stages of the disease. Thus, orexin-A might be used as a potential biomarker of physical disability.

Keywords

Multiple sclerosis Melatonin Orexin Cognitive Disability 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10072_2019_3708_MOESM1_ESM.docx (20 kb)
Supplementary Table 1 (DOCX 20 kb)

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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of Neurology, Haydarpasa Numune Education and Research HospitalIstanbul UniversityIstanbulTurkey
  2. 2.Department of Neuroscience, Aziz Sancar Institute of Experimental Medical ResearchIstanbul UniversityIstanbulTurkey

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