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Effect of pallidal deep-brain stimulation on articulation rate in dystonia

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Abstract

Pallidal deep-brain stimulation of the internal globus pallidus (GPi-DBS) is an effective treatment for dystonia. However, GPi-DBS may cause important stimulation-induced side effects such as hypokinetic dysarthria, which is particularly manifested by articulation rate abnormalities. However, little data regarding the effect of the location of the electrode and stimulation parameters for pallidal stimulation on articulation rate in dystonia is available. Speech data were acquired from 18 dystonic patients with GPi-DBS and 18 matched healthy controls. Each of dystonic patients was tested twice within 1 day in both the GPi-DBS ON and GPi-DBS OFF stimulation conditions. Compared to healthy controls, the decreased diadochokinetic rate and slower articulation rate in dystonic patients were observed in both stimulation conditions. No significant differences in speech rate measures between stimulation conditions were detected with no relation to contact localization and stimulation intensity. Our findings do not support the use articulation rate as a surrogate marker of stimulation-induced changes to the speech apparatus in dystonia.

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References

  1. Tripoliti E (2010) Effects of deep brain stimulation on speech in patients with Parkinson’s disease and dystonia: Thesis submitted for the degree of Ph.D. in Neurological studies at the Institute of Neurology at the University College London, 2010

  2. Risch V, Staiger A, Ziegler W, Ott K, Scholderle T, Pelykh O, Botzel K (2015) How does GPi-DBS affect speech in primary dystonia? Brain Stimul 8:875–880

    Article  PubMed  Google Scholar 

  3. Pauls KAM, Brockelmann PJ, Hammesfahr S, Becker J, Hellerbach A, Visser-Vandewalle V, Dembeck TA, Meister IG, Timmermann L (2018) Dysarthria in pallidal deep brain stimulation in dystonia depends on the posterior location of active electrode contacts: a pilot study. Park Relat Disord 47:71–75

    Article  CAS  Google Scholar 

  4. Jech R, Ruzicka E, Urgosik D, Serranova T, Volfova M, Novakova O, Roth J, Dusek P, Mecir P (2006) Deep brain stimulation of the subthalamic nucleus affects resting EEG and visual evoked potentials in Parkinson's disease. Clin Neurophysiol 117:1017–1028

    Article  PubMed  Google Scholar 

  5. Ruzicka F, Jech R, Novakova L, Urgosik D, Vymazal J, Ruzicka E (2012) Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease. PLoS One 7:e38020

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Rusz J, Megrelishvili M, Bonnet C, Okujava M, Brozova H, Khatiashvili M, Sekhniashvili M, Janelidze M, Tolosa E, Ruzicka E (2014) A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse. J Neural Transm 121:655–664

    Article  PubMed  Google Scholar 

  7. Duffy JR (2013) Motor speech disorders: substrates, differential diagnosis and management, 3rd ed., Mosby, St. Louis, 2013

  8. Jech R, Mueller K, Urgosik D, Sieger T, Holiga S, Ruzicka F, Dusek P, Havrankova P, Vymazal J, Ruzicka E (2012) The subthalamic microlesion story in Parkinson's disease: electrode insertion-related motor improvement with relative cortico-subcortical hypoactivation in fMRI. PLoS One 7:e49056

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Klein A, Andersson J, Ardekani BA, Ashburner J, Avants B, Chiang MC, Christensen GE, Collins DL, Gee J, Hellier P, Song JH, Jenkinson M, Lepage C, Rueckert D, Thompson P, Vercauteren T, Woods RP, Mann JJ, Parsey RV (2009) Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration. Neuroimage 46:786–802

    Article  PubMed  Google Scholar 

  10. Rusz J, Tykalova T, Fecikova A, Stastna D, Urgosik D, Jech R (2018) Dualistic effect of pallidal deep brain stimulation on motor speech disorders in dystonia. Brain Stimul 11:896–903

    Article  PubMed  Google Scholar 

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Funding

This study was financially supported by the grant project offered by the Czech Science Foundation (grant no. GAČR 16-13323S and GAČR 16-19975S), by the Ministry of Health of the Czech Republic (grant no. 15-28038A), by the Research Center for Informatics (grant no. CZ.02.1.01/0.0/0.0/16_019/0000765), and by the Czech ministry of Education (PROGRES-Q27/LF1). All rights reserved.

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Authors and Affiliations

  1. Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic

    Jan Rusz & Tereza Tykalová

  2. Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University, Prague, Czech Republic

    Jan Rusz, Anna Fečíková & Robert Jech

Authors
  1. Jan Rusz
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  2. Anna Fečíková
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  3. Tereza Tykalová
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  4. Robert Jech
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Correspondence to Jan Rusz.

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The authors declare that they have no conflict of interest.

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Each participant provided written, informed consent, and the study was approved by the Ethics Committee of the General University Hospital in Prague, Czech Republic.

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Rusz, J., Fečíková, A., Tykalová, T. et al. Effect of pallidal deep-brain stimulation on articulation rate in dystonia. Neurol Sci 40, 869–873 (2019). https://doi.org/10.1007/s10072-019-3702-5

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  • DOI: https://doi.org/10.1007/s10072-019-3702-5

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