Freezing of gait in Parkinson’s disease may share the mechanisms of dystonia

  • Yasushi ShimoEmail author
  • Taku Hatano
  • Mayu Sakurai
  • Satoko Sekimoto
  • Selly Marisdina
  • Nobutaka Hattori
Letter to the Editor

Dear Editor:

Although several pathophysiological mechanisms of freezing of gait (FOG) in Parkinson’s disease (PD) have been discussed, the precise mechanism is still unclear. Functional failure of multiple neural circuits is considered to play an important role in FOG. Herein, we report a case of PD with FOG that was suspected to be caused by dystonia. In this report, we have discussed the mechanisms underlying FOG and dystonia in PD.

A 62-year-old man with a 14-year history of PD developed FOG-like gait disturbance. He took 400 mg of levodopa/carbidopa, 18 mg of rotigotine, and 200 mg of amantadine per day. He neither showed cognitive decline, evaluated based on the Japanese version of Montreal Cognitive Assessment (30 points) and Frontal Assessment Battery (18 points), nor psychiatric problems, evaluated by a trained psychiatrist. During the drug-off phase (withdrawal of anti-Parkinsonian drugs for more than 12 h), gait disturbance was observed during forward walking (FW) but was...


Compliance with ethical standards

All procedures performed in this study were in accordance with the ethical standards of the institutional committee and with the 1964 Helsinki declaration.

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

This study involved a human participant and provided written informed consent.

Supplementary material

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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of Neurology, School of MedicineJuntendo UniversityTokyoJapan
  2. 2.Department of Research and Therapeutics for Movement Disorders, School of MedicineJuntendo UniversityTokyoJapan
  3. 3.Department of Neurology Mohammad Hoesin Hospital Faculty of MedicineSriwijaya UniversityPalembangIndonesia

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