Prognostic role of Mini-Mental State Pediatric Examination (MMSPE) on neuropsychological functioning

  • Elisa CainelliEmail author
  • Deborah Lidia Di Giacomo
  • Giulia Mantegazza
  • Luca Vedovelli
  • Jacopo Favaro
  • Clementina Boniver
Original Article



The aim of this study was to evaluate the ability of the Mini-Mental State Pediatric Examinations (MMSPE) in the individuation of neuropsychological impairments.


MMSPE was administered to 60 children attending a primary or lower secondary school suffering from neurological diseases, admitted to our neuropsychology services. All children performed both a MMSPE examination and a neuropsychological evaluation. Results of neuropsychological evaluation and MMSPE were dichotomized. Positive predictive value (PPV), negative predictive value (NPV), and accuracy were also calculated.


The diagnostic performance of MMSPE showed a good overall accuracy (0.83, CI 95% 0.64–0.91), NPV (0.81, CI 95% 0.73–1.00), PPV (0.87, CI 95% 0.68–0.94), specificity (0.91, CI 95% 0.81–1.00), sensitivity (0.74, CI 95% 0.57–0.90), and odds ratio of 28.5 (CI 95% 6.6–123), p < 0.001.


MMSPE has a good prognostic ability in predicting neuropsychological problems in the context of different neurological pediatric diseases. We suggest that this instrument could greatly improve pediatric clinical practice in identifying high-risk children.


Screening Cognitive Children Clinical practice Predictive 


Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

Statement of informed consent

The Institutional Review Board of our Department approved our study and parents of children recruited gave informed consent.


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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of Developmental Psychology and SocializationUniversity of PadovaPaduaItaly
  2. 2.Paediatric Neurology and Neurophysiology Unit, Department of Women’s and Children’s HealthUniversity Hospital of PadovaPaduaItaly
  3. 3.Child Neuropsychiatry of ASST Monza BrianzaMonzaItaly
  4. 4.Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public HealthUniversity of PadovaPaduaItaly

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