Prognostic role of Mini-Mental State Pediatric Examination (MMSPE) on neuropsychological functioning
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The aim of this study was to evaluate the ability of the Mini-Mental State Pediatric Examinations (MMSPE) in the individuation of neuropsychological impairments.
MMSPE was administered to 60 children attending a primary or lower secondary school suffering from neurological diseases, admitted to our neuropsychology services. All children performed both a MMSPE examination and a neuropsychological evaluation. Results of neuropsychological evaluation and MMSPE were dichotomized. Positive predictive value (PPV), negative predictive value (NPV), and accuracy were also calculated.
The diagnostic performance of MMSPE showed a good overall accuracy (0.83, CI 95% 0.64–0.91), NPV (0.81, CI 95% 0.73–1.00), PPV (0.87, CI 95% 0.68–0.94), specificity (0.91, CI 95% 0.81–1.00), sensitivity (0.74, CI 95% 0.57–0.90), and odds ratio of 28.5 (CI 95% 6.6–123), p < 0.001.
MMSPE has a good prognostic ability in predicting neuropsychological problems in the context of different neurological pediatric diseases. We suggest that this instrument could greatly improve pediatric clinical practice in identifying high-risk children.
KeywordsScreening Cognitive Children Clinical practice Predictive
Compliance with ethical standards
Conflicts of interest
The authors declare that they have no conflict of interest.
Statement of informed consent
The Institutional Review Board of our Department approved our study and parents of children recruited gave informed consent.
- 1.Amato MP, Goretti B, Ghezzi A, Hakiki B, Niccolai C, Lori S, Moiola L, Falautano M, Viterbo RG, Patti F, Cilia S, Pozzilli C, Bianchi V, Roscio M, Martinelli V, Comi G, Portaccio E, Trojano M, MS Study Group of the Italian Neurological Society (2014) Neuropsychological features in childhood and juvenile multiple sclerosis: five-year follow-up. Neurology 83(16):1432–1438. https://doi.org/10.1212/WNL.0000000000000885 CrossRefPubMedGoogle Scholar
- 2.Wilson SJ, Baxendale S, Barr W, Hamed S, Langfitt J, Samson S, Watanabe M, Baker GA, Helmstaedter C, Hermann BP, Smith ML (2015) Indications and expectations for neuropsychological assessment in routine epilepsy care: report of the ILAE Neuropsychology Task Force, Diagnostic Methods Commission, 2013-2017. Epilepsia 56(5):674–681. https://doi.org/10.1111/epi.12962 CrossRefPubMedGoogle Scholar
- 10.Portaccio E, Goretti B, Lori S, Zipoli V, Centorrino S, Ghezzi A, Patti F, Bianchi V, Comi G, Trojano M, Amato MP, Multiple Sclerosis Study Group of the Italian Neurological Society (2009) The brief neuropsychological battery for children: a screening tool for cognitive impairment in childhood and juvenile multiple sclerosis. Mult Scler 15(5):620–626. https://doi.org/10.1177/1352458508101950 CrossRefPubMedGoogle Scholar
- 11.Scarpa P, Toraldo A, Peviani V, Bottini G (2017) Let’s cut it short: Italian standardization of the MMSPE (Mini-Mental State Pediatric Examination), a brief cognitive screening tool for school-age children. Neurol Sci 38(1):157–162. https://doi.org/10.1007/s10072-016-2743-2 CrossRefPubMedGoogle Scholar
- 12.Raven J, Raven J, Court J (1998) Manual for Raven’s Advanced Progressive matrices (1998 Edition). Oxford Psychologists Press, Oxford, UK. https://vpngate4.hrz.tu-chemnitz.de/+CSCO+1075676763663A2F2F66707562796E652E7462627479722E7172++/scholar?q=Manual+for+Raven’s+Advanced+Progressive+Matrices+%281998+edition%29&btnG=&hl=de&as_sdt=0%2C5 Google Scholar
- 13.Bisiacchi P, Cendron M, Gugliotta M, Tressoldi P, Vio C (2005) Batteria Di Valutazione Neuropsicologica per l’Età Evolutiva. Trento, Italy, EricksonGoogle Scholar
- 14.Stoppa E, Biancardi A (1997) Il test delle Campanelle modificato: una proposta per lo studio dell’attenzione in età evolutiva. Psichiatr dell’Infanzia e dell’Adolescenza 64:73–84Google Scholar
- 16.Hirtz D, Thurman DJ, Gwinn-Hardy K, Mohamed M, Chaudhuri AR, Zalutsky R (2007) How common are the “common” neurologic disorders? Neurology 68(5):326–337. https://doi.org/10.1212/01.wnl.0000252807.38124.a3 CrossRefPubMedGoogle Scholar
- 19.Cainelli E, Nosadini M, Sartori S, Suppiej A (2018) Neuropsychological and psychopathological profile of anti-nmdar encephalitis: a possible pathophysiological model for pediatric neuropsychiatric disorders. Arch Clin Neuropsychol. https://doi.org/10.1093/arclin/acy088