Advertisement

Prognostic role of Mini-Mental State Pediatric Examination (MMSPE) on neuropsychological functioning

  • Elisa CainelliEmail author
  • Deborah Lidia Di Giacomo
  • Giulia Mantegazza
  • Luca Vedovelli
  • Jacopo Favaro
  • Clementina Boniver
Original Article
  • 13 Downloads

Abstract

Objective

The aim of this study was to evaluate the ability of the Mini-Mental State Pediatric Examinations (MMSPE) in the individuation of neuropsychological impairments.

Method

MMSPE was administered to 60 children attending a primary or lower secondary school suffering from neurological diseases, admitted to our neuropsychology services. All children performed both a MMSPE examination and a neuropsychological evaluation. Results of neuropsychological evaluation and MMSPE were dichotomized. Positive predictive value (PPV), negative predictive value (NPV), and accuracy were also calculated.

Results

The diagnostic performance of MMSPE showed a good overall accuracy (0.83, CI 95% 0.64–0.91), NPV (0.81, CI 95% 0.73–1.00), PPV (0.87, CI 95% 0.68–0.94), specificity (0.91, CI 95% 0.81–1.00), sensitivity (0.74, CI 95% 0.57–0.90), and odds ratio of 28.5 (CI 95% 6.6–123), p < 0.001.

Conclusions

MMSPE has a good prognostic ability in predicting neuropsychological problems in the context of different neurological pediatric diseases. We suggest that this instrument could greatly improve pediatric clinical practice in identifying high-risk children.

Keywords

Screening Cognitive Children Clinical practice Predictive 

Notes

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

Statement of informed consent

The Institutional Review Board of our Department approved our study and parents of children recruited gave informed consent.

References

  1. 1.
    Amato MP, Goretti B, Ghezzi A, Hakiki B, Niccolai C, Lori S, Moiola L, Falautano M, Viterbo RG, Patti F, Cilia S, Pozzilli C, Bianchi V, Roscio M, Martinelli V, Comi G, Portaccio E, Trojano M, MS Study Group of the Italian Neurological Society (2014) Neuropsychological features in childhood and juvenile multiple sclerosis: five-year follow-up. Neurology 83(16):1432–1438.  https://doi.org/10.1212/WNL.0000000000000885 CrossRefPubMedGoogle Scholar
  2. 2.
    Wilson SJ, Baxendale S, Barr W, Hamed S, Langfitt J, Samson S, Watanabe M, Baker GA, Helmstaedter C, Hermann BP, Smith ML (2015) Indications and expectations for neuropsychological assessment in routine epilepsy care: report of the ILAE Neuropsychology Task Force, Diagnostic Methods Commission, 2013-2017. Epilepsia 56(5):674–681.  https://doi.org/10.1111/epi.12962 CrossRefPubMedGoogle Scholar
  3. 3.
    Wilson SJ, Baxendale S (2014) The new approach to classification: rethinking cognition and behavior in epilepsy. Epilepsy Behav 41:307–310.  https://doi.org/10.1016/j.yebeh.2014.09.011 CrossRefPubMedGoogle Scholar
  4. 4.
    Suppiej A, Cainelli E (2014) Cognitive dysfunction in pediatric multiple sclerosis. Neuropsychiatr Dis Treat 10:1385–1392.  https://doi.org/10.2147/NDT.S48495 CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Suppiej A, Cainelli E, Casara G, Cappellari A, Nosadini M, Sartori S (2014) Long-term neurocognitive outcome and quality of life in pediatric acute disseminated encephalomyelitis. Pediatr Neurol 50(4):363–367CrossRefGoogle Scholar
  6. 6.
    Suppiej A, Traverso A, Baggio L et al (2016) Long-term neuropsychological outcome and quality of life in perinatal ischemic stroke. J Pediatr Neurol Med 1(1):1–6.  https://doi.org/10.4172/jpnm.1000104 CrossRefGoogle Scholar
  7. 7.
    Morrison CE, Macallister WS, Barr WB (2018) Neuropsychology within a tertiary care epilepsy center. Arch Clin Neuropsychol 33(3):354–364.  https://doi.org/10.1093/arclin/acx134 CrossRefPubMedGoogle Scholar
  8. 8.
    Cengiz O, Atalar AÇ, Tekin B, Bebek N, Baykan B, Gürses C (2019) Impact of seizure-related injuries on quality of life. Neurol Sci 40(3):577–583.  https://doi.org/10.1007/s10072-018-3697-3 CrossRefPubMedGoogle Scholar
  9. 9.
    Kim EH, Ko TS (2016) Cognitive impairment in childhood onset epilepsy: up-to-date information about its causes. Korean J Pediatr 59(4):155–164.  https://doi.org/10.3345/kjp.2016.59.4.155 CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Portaccio E, Goretti B, Lori S, Zipoli V, Centorrino S, Ghezzi A, Patti F, Bianchi V, Comi G, Trojano M, Amato MP, Multiple Sclerosis Study Group of the Italian Neurological Society (2009) The brief neuropsychological battery for children: a screening tool for cognitive impairment in childhood and juvenile multiple sclerosis. Mult Scler 15(5):620–626.  https://doi.org/10.1177/1352458508101950 CrossRefPubMedGoogle Scholar
  11. 11.
    Scarpa P, Toraldo A, Peviani V, Bottini G (2017) Let’s cut it short: Italian standardization of the MMSPE (Mini-Mental State Pediatric Examination), a brief cognitive screening tool for school-age children. Neurol Sci 38(1):157–162.  https://doi.org/10.1007/s10072-016-2743-2 CrossRefPubMedGoogle Scholar
  12. 12.
  13. 13.
    Bisiacchi P, Cendron M, Gugliotta M, Tressoldi P, Vio C (2005) Batteria Di Valutazione Neuropsicologica per l’Età Evolutiva. Trento, Italy, EricksonGoogle Scholar
  14. 14.
    Stoppa E, Biancardi A (1997) Il test delle Campanelle modificato: una proposta per lo studio dell’attenzione in età evolutiva. Psichiatr dell’Infanzia e dell’Adolescenza 64:73–84Google Scholar
  15. 15.
    Caffarra P, Vezzadini G, Dieci F, Zonato F, Venneri A (2002) Rey-Osterrieth complex figure: normative values in an Italian population sample. Neurol Sci 22(6):443–447.  https://doi.org/10.1007/s100720200003 CrossRefPubMedGoogle Scholar
  16. 16.
    Hirtz D, Thurman DJ, Gwinn-Hardy K, Mohamed M, Chaudhuri AR, Zalutsky R (2007) How common are the “common” neurologic disorders? Neurology 68(5):326–337.  https://doi.org/10.1212/01.wnl.0000252807.38124.a3 CrossRefPubMedGoogle Scholar
  17. 17.
    Schraegle WA, Titus JB (2017) The relationship of seizure focus with depression, anxiety, and health-related quality of life in children and adolescents with epilepsy. Epilepsy Behav 68:115–122.  https://doi.org/10.1016/j.yebeh.2016.12.009 CrossRefPubMedGoogle Scholar
  18. 18.
    Prasad AN, Corbett B (2017) Epilepsy, birth weight and academic school readiness in Canadian children: data from the national longitudinal study of children and youth. Epilepsy Res 130:101–106.  https://doi.org/10.1016/j.eplepsyres.2017.01.003 CrossRefPubMedGoogle Scholar
  19. 19.
    Cainelli E, Nosadini M, Sartori S, Suppiej A (2018) Neuropsychological and psychopathological profile of anti-nmdar encephalitis: a possible pathophysiological model for pediatric neuropsychiatric disorders. Arch Clin Neuropsychol.  https://doi.org/10.1093/arclin/acy088
  20. 20.
    Jin Y, Liu J, Wang W, Wang Y, Yin Y, Xin X, Han B (2018) Neuropsychological development in school-aged children after surgery or transcatheter closure for ventricular septal defect. Neurol Sci 39(12):2053–2060.  https://doi.org/10.1007/s10072-018-3537-5 CrossRefPubMedGoogle Scholar
  21. 21.
    Westmacott R, Macgregor D, Askalan R, Deveber G (2009) Late emergence of cognitive deficits after unilateral neonatal stroke. Stroke 40(6):2012–2019.  https://doi.org/10.1161/STROKEAHA.108.533976 CrossRefPubMedGoogle Scholar

Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of Developmental Psychology and SocializationUniversity of PadovaPaduaItaly
  2. 2.Paediatric Neurology and Neurophysiology Unit, Department of Women’s and Children’s HealthUniversity Hospital of PadovaPaduaItaly
  3. 3.Child Neuropsychiatry of ASST Monza BrianzaMonzaItaly
  4. 4.Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public HealthUniversity of PadovaPaduaItaly

Personalised recommendations