Letter regarding the article “Which cognitive dual-task walking causes most interference on the Timed Up and Go test in Parkinson’s disease: a controlled study”
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Letter to Editor,
Gait disorder is accepted as a cardinal finding of Parkinson’s disease (PD). Arrestingly, whereas voice and face akinesia have been reported to be the first signs to appear clinically, only subtle gait changes may be recognized in the early phase of PD [1, 2], such that they are not detectable under undisturbed walking conditions in the prodromal phase. This has been associated with the satisfactory motor system mechanisms compensating the slowly progressive disruption of the motor networks related to dopamine degradation within and outside the basal ganglia . Basically, increased activity in lateral premotor and parietal areas, increase in cortico-striatal excitatory input to the basal ganglia, or compensatory use of executive attention control have constituted the forefront mechanism to explain the compensation of gait disorders in the early phase of PD which would not be sufficient under dual-task conditions leading to recognition of gait disturbances in the...
KeywordsCognitive dual-task Parkinson’s disease Timed up and Go test Locomotion Pathophysiology
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This report was in accordance with Declaration of Helsinki.