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Association between alpha-synuclein (SNCA) rs11931074 variability and susceptibility to Parkinson’s disease: an updated meta-analysis of 41,811 patients

  • Bingying Du
  • Qiang Xue
  • Caiquan Liang
  • Cunxiu Fan
  • Meng Liang
  • Yanbo Zhang
  • Xiaoying BiEmail author
  • Lijun HouEmail author
Review Article

Abstract

Background and objectives

Parkinson’s disease (PD) is one of the most common forms of neurodegenerative disorders, and its etiology remains unclear. Single nucleotide polymorphisms (SNPs) of alpha-synuclein (SNCA) have been found to be significantly associated with PD risk. In particular, the variant rs11931074 was found in one meta-analysis to appear to play a role in the occurrence of PD. This finding has been questioned in subsequent studies, however. The aim of this study was to determine the relationship between PD risk and rs11931074 polymorphism.

Methods

We performed a systematic online search, including PubMed, Web of Science, EMBASE, Cochrane Library, and CNKI (China National Knowledge Infrastructure), aiming to identify case–control studies looking at the role of rs11931074 in PD. We performed calculations of pooled odds ratio (OR) and 95% confidence interval (95% CI) to assess the associations, and subgroup meta-analyses to verify differences between various ethnicities of different study populations.

Results

A total of 13 studies involving 13,403 cases and 28,408 controls met the inclusion criteria after assessment by two reviewers. Overall, there exists significant associations between SNCA rs11931074 polymorphism and the risk of PD under five genetic models (allele contrast model: T vs. G, OR = 1.28, 95% CI = 1.12–1.45, P = 0.0001; homozygote model: TG vs. GG, OR = 1.55, 95% CI = 1.17–2.05, P = 0.002; heterozygote model (TT vs. GG, OR = 1.23, 95% CI = 1.05–1.42, P = 0.009; dominant model: TG+TT vs. GG: OR = 1.25, 95% CI = 1.05–1.50, P = 0.01 and recessive model: TT vs. TG+GG: OR = 1.40, 95% CI = 1.18–1.68, P = 0.0002). When ethnicities were stratified, significant associations were found in the allelic, homozygote, and recessive models for Asians, and in the allelic model for Caucasians.

Conclusion

SNCA rs11931074 polymorphism is found to be associated with PD risk and this risk appears to be influenced by genetic status and ethnicity.

Keywords

SNCA Polymorphism Parkinson’s disease Meta-analysis 

Notes

Funding information

This project was funded by the National Natural Science Foundation of China (grant number 81571299).

Compliance with ethical standards

This study was carried out in accordance with the recommendations of the Ethics Committee of Second Military Medical University.

Conflict of interest

The authors declare that they have no conflict of interest

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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of Neurology, Shanghai Changhai HospitalSecond Military Medical UniversityShanghaiChina
  2. 2.Department of NeurologyGeneral Hospital of Central Theater Command of Chinese People’s Liberation ArmyWuhanChina
  3. 3.Department of Neurosurgery, Shanghai Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghaiChina
  4. 4.Department of Otolaryngology-Head and Neck Surgery, Changzheng HospitalSecond Military Medical UniversityShanghaiChina
  5. 5.Department of Psychiatry, College of MedicineUniversity of SaskatchewanSaskatoonCanada
  6. 6.Department of Neurosurgery, Shanghai Neurosurgical Institute, Changzheng HospitalSecond Military Medical UniversityShanghaiChina

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