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Neurological Sciences

, Volume 40, Issue 12, pp 2617–2624 | Cite as

Added assessment of middle cerebral artery and atrial fibrillation to FLAIR vascular hyperintensity-DWI mismatch would improve the outcome prediction of acute infarction in patients with acute internal carotid artery occlusion

  • Tao Yuan
  • Guoli Ren
  • Xianning Hu
  • Lina Geng
  • Xueqing Li
  • Shuang Xia
  • Guanmin QuanEmail author
Original Article

Abstract

Background and aims

Whether fluid-attenuated inversion recovery (FLAIR) vascular hyperintensities (FVH)-DWI mismatch could predict the outcome or not remains in debate. The aim of this study was to identify if FVH combined with the other markers improved favorable outcome prediction of acute infarctions in patients with unilateral acute internal carotid artery (ICA) occlusion.

Methods

Consecutive 68 adult acute middle cerebral artery (MCA) territory infarction patients caused by acute ICA occlusion, including favorable (n = 38, mRS ≤ 2) and unfavorable (n = 30, mRS > 2) groups, were enrolled in this retrospective analysis. The diagnostic efficiency of favorable clinical outcome of FVH-DWI mismatch was compared with those of DWI lesions volumetry and the combined marker of FVH-DWI mismatch and other factors.

Results

There were more prominent FVH-DWI mismatch (≥ 3 sections) (84%), less atrial fibrillation (AFib) (13%), and more tandem MCA normal or mild stenosis (63%) in favorable outcome group than those (30%, 40%, and 27%, respectively) in unfavorable group. Univariate and multivariate analyses showed that the prominent FVH-DWI mismatch was the positive predictive factor for favorable outcome (OR = 2.643 and 3.200). Prominent FVH-DWI mismatch, in combination with tandem MCA normal or mild stenosis, and absence of Afib, had better performance (AUC = 0.875) than that of initial DWI lesion volumetry (AUC = 0.854) and any other single factor (AUC = 0.634~0.820) in predicting favorable outcome.

Conclusions

Prominent FVH-DWI mismatch was associated with favorable outcome in acute infarctions in unilateral ICA occlusion patients. Its predictive performance would be improved when combined with the assessment of tandem lesions of MCA and AFib.

Keywords

Stroke Internal carotid artery Magnetic resonance imaging Fluid-attenuated inversion recovery Outcome 

Notes

Source of funding

This study is supported by National Natural Scientific Grant (Xia S, project no. 81871342) and Key Project in Medical Science Research of Hebei Province (Yuan T, project no. 20170615; Quan G, no. 20180362).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The Ethics Committee of The Second Hospital of Hebei Medical University approved this retrospective study. Due to the retrospective nature of this study, the informed written consent was waved.

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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of Medical ImagingThe Second Hospital of Hebei Medical UniversityShijiazhuangChina
  2. 2.Department of Medical ImagingLiaocheng People’s HospitalLiaochengChina
  3. 3.Department of Medical ImagingLingshou County People’s HospitalShijiazhuangChina
  4. 4.Department of RadiologyTianjin First Central HospitalTianjinChina

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