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BDNF Val66Met polymorphism and cognitive impairment in Parkinson’s disease—a meta-analysis

  • Yanying Yin
  • Xuening Su
  • Lishou Pan
  • Chen LiEmail author
Original Article

Abstract

Background

Conflicting results identifying the association between Brain-derived neurotrophic factor (BDNF) polymorphism, Val66Met, and cognitive impairment in Parkinson’s disease (PD) have been reported.

Methods and results

To clarify whether Val66Met is related to cognitive impairment in PD, we carried out this meta-analysis by searching literature from PubMed, Web of Science, and Embase databases regarding this polymorphism. Six eligible studies involving 1467 PD patients were included in this meta-analysis. Our results showed statistically significant association between Val66Met and risk of cognitive impairment in PD patients in additive model (Met/Met vs. Val/Val: OR 3.82, 95%CI 1.32 to 11.08, p = 0.01) and recessive model (Met/Met vs. Val-carrier: OR 3.81, 95%CI 1.38 to 10.53, p = 0.01) except for dominant model.

Conclusions

Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson’s disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research.

Keywords

BDNF Polymorphism PD-related cognitive impairment  Meta-analysis 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of NeurologyThe Fifth Central Hospital of TianjinTianjinPeople’s Republic of China
  2. 2.Department of Neurology, The People’s Hospital of Yichun CityYichun UniversityYichunPeople’s Republic of China

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