Dystonin/BPAG1 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis

  • Jack Cheng
  • Hsin-Ping Liu
  • Su-Lun Hwang
  • Lee-Fen Hsu
  • Wei-Yong LinEmail author
  • Fuu-Jen TsaiEmail author
Original Article


Dementia is one of the diabetic complications under intensive study. Alteration of synaptic adhesion protein (SAP) associates with neurological diseases, including Alzheimer’s disease. However, the regulation of SAPs in the brain of diabetes mellitus remains elusive. To pinpoint the candidate SAPs underlining the mechanism of diabetic dementia, we investigated expression profiling of SAPs in both streptozotocin (STZ)-induced diabetic mice, AppNL-G-F/NL-G-F mice, and amyloid precursor protein intracellular domain (AICD)-induced human neural cell line from public databases. DST (Dystonin/BPAG1) was identified upregulated in both models. Our finding suggests that DST alteration may involve in the mechanism of diabetic dementia.


Synaptic adhesion protein Dystonin Diabetic dementia 



Synaptic adhesion protein




Amyloid precursor protein intracellular domain


Alzheimer’s disease


Bullous pemphigoid


Funding information

This work was supported by grants from the Ministry of Science and Technology in Taiwan (MOST 106-2320-B-039-023, MOST 107-2314-B-039 -042 -MY2, MOST 104-2320-B-039-009, MOST 105-2632-B-039-002, MOST 106-2632-B-039-001) and grants from China Medical University and Hospital (CMU107-S-51, CMU107-S-08, CMU104-S-14-03, CMU105-S-53, DMR-101-065, and DMR-103-099). This study is also supported in part by the Chang Gung Memorial Hospital (grants CMRPF6D0051, CMRPF6D0052, CMRPF6D0053).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Graduate Institute of Integrated Medicine, College of Chinese MedicineChina Medical UniversityTaichungTaiwan
  2. 2.Department of Medical ResearchChina Medical University HospitalTaichungTaiwan
  3. 3.Graduate Institute of Acupuncture Science, College of Chinese MedicineChina Medical UniversityTaichungTaiwan
  4. 4.Department of Bioinformatics and Medical EngineeringAsia UniversityTaichungTaiwan
  5. 5.Department of NursingChang Gung University of Science and TechnologyChiayi CountyTaiwan
  6. 6.Division of Pulmonary and Critical Care MedicineChang Gung Memorial HospitalChiayi CountyTaiwan
  7. 7.Department of Respiratory CareChang Gung University of Science and TechnologyChiayi CountyTaiwan
  8. 8.Division of Neurosurgery, Department of SurgeryChang Gung Memorial HospitalChiayi CountyTaiwan
  9. 9.Brain Diseases Research CenterChina Medical UniversityTaichungTaiwan
  10. 10.School of Chinese MedicineChina Medical UniversityTaichungTaiwan
  11. 11.Department of BiotechnologyAsia UniversityTaichungTaiwan
  12. 12.Children’s Medical CenterChina Medical University HospitalTaichungTaiwan

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