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Dystonin/BPAG1 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis

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Abstract

Dementia is one of the diabetic complications under intensive study. Alteration of synaptic adhesion protein (SAP) associates with neurological diseases, including Alzheimer’s disease. However, the regulation of SAPs in the brain of diabetes mellitus remains elusive. To pinpoint the candidate SAPs underlining the mechanism of diabetic dementia, we investigated expression profiling of SAPs in both streptozotocin (STZ)-induced diabetic mice, AppNL-G-F/NL-G-F mice, and amyloid precursor protein intracellular domain (AICD)-induced human neural cell line from public databases. DST (Dystonin/BPAG1) was identified upregulated in both models. Our finding suggests that DST alteration may involve in the mechanism of diabetic dementia.

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Abbreviations

SAP:

Synaptic adhesion protein

STZ:

Streptozotocin

AICD:

Amyloid precursor protein intracellular domain

AD:

Alzheimer’s disease

BP:

Bullous pemphigoid

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Funding

This work was supported by grants from the Ministry of Science and Technology in Taiwan (MOST 106-2320-B-039-023, MOST 107-2314-B-039 -042 -MY2, MOST 104-2320-B-039-009, MOST 105-2632-B-039-002, MOST 106-2632-B-039-001) and grants from China Medical University and Hospital (CMU107-S-51, CMU107-S-08, CMU104-S-14-03, CMU105-S-53, DMR-101-065, and DMR-103-099). This study is also supported in part by the Chang Gung Memorial Hospital (grants CMRPF6D0051, CMRPF6D0052, CMRPF6D0053).

Author information

Author notes

  1. Jack Cheng, Hsin-Ping Liu and Su-Lun Hwang contributed equally to this work.

Authors and Affiliations

  1. Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan

    Jack Cheng & Wei-Yong Lin

  2. Department of Medical Research, China Medical University Hospital, Taichung, 40447, Taiwan

    Jack Cheng, Wei-Yong Lin & Fuu-Jen Tsai

  3. Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan

    Hsin-Ping Liu

  4. Department of Bioinformatics and Medical Engineering, Asia University, Taichung, 41354, Taiwan

    Hsin-Ping Liu

  5. Department of Nursing, Chang Gung University of Science and Technology, Chiayi County, 61363, Taiwan

    Su-Lun Hwang

  6. Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi County, 61363, Taiwan

    Su-Lun Hwang

  7. Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi County, 61363, Taiwan

    Lee-Fen Hsu

  8. Division of Neurosurgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi County, 61363, Taiwan

    Lee-Fen Hsu

  9. Brain Diseases Research Center, China Medical University, Taichung, 40402, Taiwan

    Wei-Yong Lin

  10. School of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan

    Fuu-Jen Tsai

  11. Department of Biotechnology, Asia University, Taichung, 41354, Taiwan

    Fuu-Jen Tsai

  12. Children’s Medical Center, China Medical University Hospital, Taichung, 40447, Taiwan

    Fuu-Jen Tsai

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  1. Jack Cheng
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  2. Hsin-Ping Liu
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  3. Su-Lun Hwang
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Correspondence to Wei-Yong Lin or Fuu-Jen Tsai.

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Cheng, J., Liu, HP., Hwang, SL. et al. Dystonin/BPAG1 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis. Neurol Sci 40, 1577–1582 (2019). https://doi.org/10.1007/s10072-019-03879-3

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  • DOI: https://doi.org/10.1007/s10072-019-03879-3

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