Combined hypertrophic olivary degeneration and Wallerian degeneration of the bilateral middle cerebellar peduncles: a case report
- 27 Downloads
Hypertrophic olivary degeneration (HOD), a rare condition, is characterized by a unique pattern of trans-synaptic degeneration caused by injury to the brainstem or cerebellum within the triangle of Guillain and Mollaret . Bilateral Wallerian degeneration (WD) of the middle cerebellar peduncles is caused by interruption of crossed cortico-ponto-cerebellar pathways and is rarely reported in the literature . The three most common types of main transaxonal degeneration involving cerebellar connections are hypertrophic olivary degeneration, Wallerian degeneration of the middle cerebellar peduncle, and crossed cerebellar diaschisis (CCD). The occurrence of any one of these phenomena is very rare, and they are therefore usually reported separately in the literature. Here, we report a patient who presented with the neuroradiological findings of WD involving the bilateral middle cerebellar peduncles secondary to brainstem hemorrhage, as well as abnormal signaling in the...
The authors thank Longnv Luo and Daokuan Zhou for her assistance in the preparation of the manuscript.
This work was financially supported by Key Research Program for Higher Education of Henan Province, China (ID 18A320071).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Konno T, Broderick DF, Tacik P, Caviness JN, Wszolek ZK (2016) Hypertrophic olivary degeneration: a clinico-radiologic study. Parkinsonism Relat Disord 28:36–40. https://doi.org/10.1016/j.parkreldis.2016.04.008
- 2.Shen Y, Nie H,(2018) Wallerian degeneration of the bilateral middle cerebellar peduncles secondary to pontine infarction. Neurological Sciences 39 (5):961–963Google Scholar
- 3.Goto N, Kaneko M (1981) Olivary enlargement: chronological and morphometric analyses. Acta Neuropathol 54(4):275–282Google Scholar
- 4.Kalla R, Meichtry J, Schumacher R, Cazzoli D, Wiest R, Seifert E, Müri R (2016) Dancing jaw and dancing eyes. JAMA Neurol 73(1):122. https://doi.org/10.1001/jamaneurol.2015.2299
- 5.Matsuo F, Ajax ET (1979) Palatal myoclonus and denervation supersensitivity in the central nervous system. Ann Neurol 5(1):72–78. https://doi.org/10.1002/ana.410050111
- 6.Zhou C, He Y, Chao Z, Zhu Y, Wang P, Wang X, Liu S, Han W, Wang J (2017) Wernekink commissure syndrome secondary to bilateral caudal paramedian midbrain infarction presenting with a unique “heart or V” appearance sign: case report and review of the literature. Front Neurol 8:376. https://doi.org/10.3389/fneur.2017.00376
- 7.De Simone T, Regna-Gladin C, Carriero MR, Farina L et al (2005) Wallerian degeneration of the pontocerebellar fibers. AJNR 26:1062–1065Google Scholar
- 8.Nabavizadeh SA, Mowla A, Mamourian AC (2015) Wallerian degeneration of the bilateral middle cerebellar peduncles.[J]. J Neurol Sci 349:256–257Google Scholar