Combined hypertrophic olivary degeneration and Wallerian degeneration of the bilateral middle cerebellar peduncles: a case report

  • Chenguang ZhouEmail author
  • Zhuanli QinEmail author
  • Yaoyao Shen
  • Ning Han
  • Yi Sui
  • Yinghui Zhu
  • Yuanhong He
Letter to the Editor

Dear Editor,

Hypertrophic olivary degeneration (HOD), a rare condition, is characterized by a unique pattern of trans-synaptic degeneration caused by injury to the brainstem or cerebellum within the triangle of Guillain and Mollaret [1]. Bilateral Wallerian degeneration (WD) of the middle cerebellar peduncles is caused by interruption of crossed cortico-ponto-cerebellar pathways and is rarely reported in the literature [2]. The three most common types of main transaxonal degeneration involving cerebellar connections are hypertrophic olivary degeneration, Wallerian degeneration of the middle cerebellar peduncle, and crossed cerebellar diaschisis (CCD). The occurrence of any one of these phenomena is very rare, and they are therefore usually reported separately in the literature. Here, we report a patient who presented with the neuroradiological findings of WD involving the bilateral middle cerebellar peduncles secondary to brainstem hemorrhage, as well as abnormal signaling in the...



The authors thank Longnv Luo and Daokuan Zhou for her assistance in the preparation of the manuscript.

Funding disclosure

This work was financially supported by Key Research Program for Higher Education of Henan Province, China (ID 18A320071).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of NeurologyThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina
  2. 2.The Department of RadiologyXuchang Municipal Hospital of HenanXuchangChina
  3. 3.Department of NeurologyThe Affiliated Hospital of Jiujiang UniversityJiangxiChina
  4. 4.The Department of NeurologyHebei General HospitalHebeiChina
  5. 5.Department of Neurology, Shenyang First People’s Hospital, Shenyang Brain InstituteShenyang Medical College Affiliated Shenyang Brain HospitalShenyangChina

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