Attenuation of ALS progression during pregnancy—lessons to be learned or just a coincidence?

  • Mirea HancevicEmail author
  • Hrvoje Bilic
  • Barbara Sitas
  • Gordana Pavlisa
  • Fran Borovecki
  • Ivana Munitic
  • Ervina Bilic
Brief Communication


ALS is the most frequent motor neuron disorder in adults with suggested complex relationship regarding gender. Studies investigating ALS and hormones have provided varying results. ALS onset during pregnancy is uncommon and pregnancy after the ALS symptom onset is even rarer. We present three patients with the onset of ALS symptoms before or during pregnancy and propose a putative disease modifying mechanism leading to attenuation of disease progression that we observed during the pregnancies.


ALS Pregnancy Hormones Gender Immunomodulation FUS 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants for whom identifying information is included in this article.


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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Department of NeurologyClinical Hospital Centre ZagrebZagrebCroatia
  2. 2.Department of PulmonologyClinical Hospital Centre ZagrebZagrebCroatia
  3. 3.School of MedicineUniversity of ZagrebZagrebCroatia
  4. 4.Laboratory of Molecular Immunology, Department of BiotechnologyUniversity of RijekaRijekaCroatia

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