Vastus lateralis myofascial free flap for tongue reconstruction and hypoglossal-femoral anastomosis: neurophysiological study

  • Edvina Galiè
  • Veronica VillaniEmail author
  • Fabio Ferreli
  • Andrea Pace
  • Raul Pellini
Original Article



Total or nearly glossectomy with laryngeal preservation may lead to development of dysfunction speech, chewing, and swallowing with orally disabled. Pellini et al. analyze the feasibility of vastus lateralis myofascial free flap (VLMFF) in tongue reconstruction and demonstrated that this treatment offers a better cosmetic result in tongue reconstruction, an adequate bulk when needed, a mass reduction of neo-tongue after 30 days post-surgery of 20–30%, an optimal functional results, and an obliteration of dead space and with thus preventing fistulas and infections with minimal morbidity. The aim of our study was to evaluate the innervation of tongue reconstruction performed with nerve anastomosis between the unilateral hypoglossal nerve and branch for vastus lateralis muscle of femoral nerve with neurophysiological study.


We performed a neurophysiological evaluation of four patients who underwent surgery and observed a reinnervation of tongue flap by the anastomosis hypoglossal-femoral nerve for the reconstruction of neo-tongue with vastus lateralis myofascial free flap. The reconstruction of neo-tongue with vastus lateralis myofascial free flap may be represent a valid surgery for patients with cancer tongue.


Tongue Reconstruction Neurophysiological study Cancer 


Authors’ contributions

Edvina Galié and Raoul Pellini study concepts and design, draft/revise the manuscript, analyze or interpret the data, accept responsibility for conduct of research and final approval, and acquire the data. Ferreli and Villani acquire the data, revise the manuscript, and accept responsibility for conduct of research and final approval. A Pace analyzes or interprets the data and accepts responsibility for conduct of research and final approval.

Compliance with ethical standards

The local Institutional Review Board approved the study, and each patient provided a valid informed consent before enrollment.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Fondazione Società Italiana di Neurologia 2019

Authors and Affiliations

  1. 1.Neuroncology Unit, IRCCS Regina Elena National Cancer InstituteRomeItaly
  2. 2.Department of Otolaryngology-Head and Neck SurgeryIRCCS Regina Elena National Cancer InstituteRomeItaly

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