Neurological Sciences

, Volume 40, Issue 5, pp 1083–1085 | Cite as

Bilateral trigeminal root entry zone enhancement in MOG-IgG-associated brainstem encephalitis

  • Yaoyao ShenEmail author
  • Zhijuan Cheng
  • Chenguang Zhou
Letter to the Editor

Dear editor,

Over the past few years, IgG antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have attracted more attention in inflammatory demyelinating diseases of the central nervous system (CNS). Recent studies support the viewpoint that MOG-IgG-associated encephalomyelitis (MOG-EM) may be a disease entity in its own right, immunopathogenetically distinct from classic multiple sclerosis (MS) and AQP4-IgG-positive neuromyelitis optica spectrum disorders (NMOSD) [1]. The incidence of brainstem involvement among patients with MOG-EM is estimated to be almost one-third [2]. Up to our knowledge, the pontine trigeminal root entry zone (REZ) abnormality is frequently described in MS but extremely rare in MOG-EM [3]. We herein describe an interesting neuroradiological finding of bilateral trigeminal REZ enhancement in a patient with MOG-IgG-associated brainstem encephalitis.

A previously healthy 51-year-old woman was admitted to local hospital owing to intractable nausea and...



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Copyright information

© Fondazione Società Italiana di Neurologia 2018

Authors and Affiliations

  1. 1.Department of NeurologyThe Affiliated Hospital of Jiujiang UniversityJiujiangPeople’s Republic of China
  2. 2.Department of NeurologyThe Second Affiliated Hospital of Nanchang UniversityNanchangPeople’s Republic of China
  3. 3.Department of NeurologyThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouPeople’s Republic of China

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