Neurological Sciences

, Volume 40, Issue 5, pp 1081–1082 | Cite as

An unusual case of PML in HIV patient presenting with diplopia

  • L. Romano
  • E. Capiluppi
  • A. Macerollo
  • G. CislaghiEmail author
Letter to the Editor

Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease secondary to JC virus reactivation presenting with multifocal neurologic signs [1]. Diplopia is a neurological symptom due to dysfunction at the level of the neuromuscular junction, cranial nerves, or brainstem. Infective, autoimmune, or neoplastic/paraneoplastic diseases may cause diplopia. Here, we present a case of diplopia at the onset of PML in a patient with positivity for human immunodeficiency virus (HIV). Informed consent was obtained from the patient included in the study.

A 43-year-old HIV-positive and favic female patient was admitted to Neurological Clinic of Sacco Hospital (Milan, Italy) on 1 July 2009 due to subacute onset of diplopia. Her HIV positivity was known since 1989. Notably, CD4 cell counts were 300 mm 3. Tick-borne and fever (37.5 °C) were reported 10 days prior to the onset of diplopia and 30 days prior to the admission. The neurological examination showed diplopia, horizontal...



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Copyright information

© Fondazione Società Italiana di Neurologia 2018

Authors and Affiliations

  1. 1.Chair of Neurology, Department of Clinical Sciences “Luigi Sacco”- L. Sacco HospitalUniversity of MilanMilanItaly
  2. 2.The Walton Center NHS Foundation TrustLiverpoolUK
  3. 3.Institute of NeurologyUniversity College of LondonLondonUK

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