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Neurological Sciences

, Volume 40, Issue 1, pp 181–186 | Cite as

The reversible effect of neck flexion on the somatosensory evoked potentials in patients with Hirayama disease: a preliminary study

  • Jin-Sung Park
  • Jin Young Ko
  • Donghwi ParkEmail author
Original Article
  • 39 Downloads

Abstract

The aim of this study was to examine and characterize the reversibility of the cervical somatosensory electrophysiological pathways during neutral and flexed neck positions. The parameters of somatosensory evoked potentials (SEPs) during neutral and flexed neck positions (N9, N13, and N20 SEP latencies; N9–N13 and N13–N20 inter-peak latencies; and the changes in N9–N13 and N13–N20 inter-peak latency during neutral and flexed neck positions) were measured in the patients with Hirayama disease (HD) and also in the healthy controls. In patients with HD, there was a significant difference in the mean value of N13–N20 inter-peak latency during the flexed neck position compared to that of the healthy controls (p < 0.05). In a multivariate logistic regression analysis, N13–N20 inter-peak latency during the flexed neck position significantly correlated with the presence of HD (p < 0.05). Collectively, in this cohort of patients with HD, the neck flexion of patients with HD showed a reversible effect on the SEP parameter, especially in N13–N20 inter-peak latency. Conventional diagnosis of HD is based on nerve conduction studies and electromyography along with a cervical flexion MRI, and our study suggests the possibility of an additional and cost-effective electrophysiological marker that may be helpful in the diagnosis of HD.

Keywords

Hirayama Sensory evoked potentials Neck flexion MRI Motor neuron disease 

Notes

Funding information

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1D1A1B03033127). This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science and ICT) (No. 2017R1C1B5076264).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurologySchool of Medicine, Kyungpook National UniversityDaeguKorea
  2. 2.Department of Rehabilitation MedicineSeoul National University Bundang HospitalSeongnam-siSouth Korea
  3. 3.Department of Rehabilitation MedicineDaegu Fatima HospitalDaeguSouth Korea

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