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Neurological Sciences

, Volume 40, Issue 1, pp 127–132 | Cite as

Olfactory bulb atrophy in migraine patients

  • Tülin AktürkEmail author
  • Nermin Tanık
  • Halil İbrahim Serin
  • Hikmet Saçmacı
  • Levent Ertuğrul İnan
Original Article

Abstract

Objective

Osmophobia and headache triggered by odors are commonly seen in migraine, and these are symptoms that differentiate migraine from other primary headaches. Since these odor-related symptoms are disease-specific, we aimed to measure the volume of olfactory bulb and depth of olfactory sulcus in migraine patients.

Patients and method

A total of 93 subjects, consisting of 62 episodic migraine (32 with osmophobia, 30 without osmophobia) patients and 31 healthy controls, were included in this study. Diagnosis and classification of migraine were performed according to the beta version criteria of International Classification of Headache Disorders (ICHD-3 Beta version). Beck depression and beck anxiety inventory were applied to the patients, and the measurement of bilateral olfactory bulb volume (OBV) and olfactory sulcus depth (OSD) was performed manually in the brain magnetic resonance imaging (MRI).

Results

More significantly in the left OBV, low OBV has been determined in migraine patients compared to the control group (p < 0.001, p = 0.020). When migraine patients with or without osmophobia were compared to the control group; OBV was determined to be the lowest in migraine group with osmophobia, and left-weighted bilateral OBV was determined to be low (p < 0.001, p = 0.046). No statistically significant difference was determined between groups in OSD measurements (p = 0.646, p = 0.490).

Conclusion

Left-weighted bilateral OBV atrophy determined in migraine patients may be guiding for the clarification of migraine pathophysiology and enlightening of the relation between migraine and odor.

Keywords

Migraine Olfactory bulb atrophy Osmophobia Neurodegeneration 

Notes

Compliance with ethical standards

Bozok University School of Medicine Ethics Committee approved the study protocol (protocol number: 2017-KAEK-189_2017.06.21_03) and all the participants provided written informed consent.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurologyBozok University Medical SchoolYozgatTurkey
  2. 2.Department of RadiologyBozok University Medical SchoolYozgatTurkey
  3. 3.Department of NeurologyMinistry of Health Ankara Research and Training HospitalAnkaraTurkey

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