Olfactory bulb atrophy in migraine patients
Osmophobia and headache triggered by odors are commonly seen in migraine, and these are symptoms that differentiate migraine from other primary headaches. Since these odor-related symptoms are disease-specific, we aimed to measure the volume of olfactory bulb and depth of olfactory sulcus in migraine patients.
Patients and method
A total of 93 subjects, consisting of 62 episodic migraine (32 with osmophobia, 30 without osmophobia) patients and 31 healthy controls, were included in this study. Diagnosis and classification of migraine were performed according to the beta version criteria of International Classification of Headache Disorders (ICHD-3 Beta version). Beck depression and beck anxiety inventory were applied to the patients, and the measurement of bilateral olfactory bulb volume (OBV) and olfactory sulcus depth (OSD) was performed manually in the brain magnetic resonance imaging (MRI).
More significantly in the left OBV, low OBV has been determined in migraine patients compared to the control group (p < 0.001, p = 0.020). When migraine patients with or without osmophobia were compared to the control group; OBV was determined to be the lowest in migraine group with osmophobia, and left-weighted bilateral OBV was determined to be low (p < 0.001, p = 0.046). No statistically significant difference was determined between groups in OSD measurements (p = 0.646, p = 0.490).
Left-weighted bilateral OBV atrophy determined in migraine patients may be guiding for the clarification of migraine pathophysiology and enlightening of the relation between migraine and odor.
KeywordsMigraine Olfactory bulb atrophy Osmophobia Neurodegeneration
Compliance with ethical standards
Bozok University School of Medicine Ethics Committee approved the study protocol (protocol number: 2017-KAEK-189_2017.06.21_03) and all the participants provided written informed consent.
Conflict of interest
The authors declare that they have no conflict of interest.
- 10.Physical status: the use and interpretation of anthropometry (1995). Report of a WHO expert committee. World Health Organ Tech Rep Ser 854: 1–452Google Scholar
- 15.Li WL, Chu MW, Wu A et al (2018) Adult-born neurons facilitate olfactory bulb pattern separation during task engagement. Elife 13:1–26Google Scholar
- 17.Li J, Gu CZ, Su JB et al (2016) Changes in olfactory bulb volume in Parkinson’s disease: a systematic review and meta-analysis. PLoS One 11:1–14Google Scholar
- 18.Yaldizli Ö, Penner IK, Yonekawa T, Naegelin Y, Kuhle J, Pardini M, Chard DT, Stippich C, Kira JI, Bendfeldt K, Amann M, Radue EW, Kappos L, Sprenger T (2016) The association between olfactory bulb volume, cognitive dysfunction, physical disability and depression in multiple sclerosis. Eur J Neurol 23:510–519CrossRefGoogle Scholar
- 30.Mehnert J, May A (2017) Functional and structural alterations in the migraine cerebellum. J Cereb Blood Flow Metab. https://doi.org/10.1177/0271678X17722109
- 34.Abdellatif MK, Fouad MM (2018) Effect of duration and severity of migraine on retinal nerve fiber layer, ganglion cell layer, and choroidal thickness. Eur J Ophthalmol. https://doi.org/10.1177/1120672117750054
- 35.Szabó N, Faragó P, Király A, Veréb D, Csete G, Tóth E, Kocsis K, Kincses B, Tuka B, Párdutz Á, Szok D, Tajti J, Vécsei L, Kincses ZT (2018) Evidence for plastic processes in migraine with aura: a diffusion weighted MRI study. Front Neuroanat 11:138. https://doi.org/10.3389/fnana.2017.00138 CrossRefPubMedPubMedCentralGoogle Scholar