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Neurological Sciences

, Volume 39, Issue 9, pp 1565–1569 | Cite as

Expression analysis of beta-secretase 1 (BACE1) and its naturally occurring antisense (BACE1-AS) in blood of epileptic patients

  • Mehrdokht Mazdeh
  • Alireza Komaki
  • Mir Davood Omrani
  • Vajihe Gharzi
  • Arezou Sayad
  • Mohammad Taheri
  • Soudeh Ghafouri-Fard
Original Article
  • 44 Downloads

Abstract

Beta-secretase 1 (BACE1) gene encodes a transmembrane protease from the peptidase A1 family of aspartic proteases whose role in the pathogenesis of Alzheimer’s disease has been assessed. The enzymatic activity of BACE1 on several proteins implicated in epileptogenesis implies its role in the pathogenesis of epilepsy. In the present study, we assessed expression of BACE1 and its naturally occurring antisense (BACE1-AS) in peripheral blood of 40 epileptic patients and 40 age- and sex-matched healthy subjects. We did not detect either any difference in the expression of these genes between cases and controls or significant correlation between their expressions and participants’ age. However, we demonstrated a significant correlation between expression levels of BACE1 and BACE1-AS which supports the previously suggested feed-forward mechanism of regulation between these two transcripts. Future studies in larger sample sizes are needed to elaborate the function of BACE1 in epilepsy.

Keywords

BACE1 BACE1-AS Epilepsy 

Notes

Funding information

The current study has been supported by a grant from the Hamadan University of Medical Sciences (Grant Number 9609286012).

Compliance with ethical standards

The local ethical committee of Hamadan University of Medical Sciences(IR.UMSHA.REC.1396.578)approved the study.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Neurophysiology Research CenterHamadan University of Medical SciencesHamadanIran
  2. 2.Department of NeurologyHamadan University of Medical SciencesHamadanIran
  3. 3.Department of Medical GeneticsShahid Beheshti University of Medical SciencesTehranIran
  4. 4.Urogenital Stem Cell Research CenterShahid Beheshti University of Medical SciencesTehranIran

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