Bilateral vestibular impairment in Vogt Koyanagi Harada syndrome: a case report
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Vogt Koyanagi Harada (VKH) syndrome is an autoimmune disorder that targets melanocytes and melanocyte-associated antigens. It is characterized by chorioretinitis, but may include neurological, dermatological, and audio-vestibular manifestations.
Hypoacusis and tinnitus may be so severe that a cochlear implant is needed, while vestibular impairment is usually mild and most often revealed only by clinical or instrumental findings.
A 58-year-old Caucasian woman was referred to our attention for vertigo and severe bilateral visual loss which had started 7 years before. At that time, there was no evidence of past or current neurological, auditory, or cutaneous manifestations. Based on the results of fundus examination, OCT, and fluorescein angiography, and in the absence of a previous penetrating ocular trauma or surgery, and the negative laboratory findings, the diagnosis of probable VKH (isolated ocular disease) was made. The vertigo sensation was explained as a consequence of the visual...
The study was funded by the Ricerca Corrente from the Italian Ministry of Health to the Mondino National Neurological Institute (RC 2015-2018).
Compliance with ethical standards
Conflict of interest
Maurizio Versino, Paolo Colagiorgio, and Stefano Ramat are shareholders of the company producing a commercial version of fHIT.
All procedures performed in this study were standard procedure aimed to make the diagnosis, and in accordance with the ethical standards of the institutional and/or national healthcare system.
Informed consent was obtained from the patient who agreed to give us the permission to submit this case report for possible publication on a scientific journal.
- 1.Colagiorgio P, Colnaghi S, Versino M, Ramat S (2013) A new tool for investigating the functional testing of the VOR. Frontiers in Neurology 4 (OCT). https://doi.org/10.3389/fneur.2013.00165
- 4.Versino M, Ranza L, Colnaghi S, Alloni R, Callieco R, Romani A, Bergamaschi R, Pichiecchio A, Bastianello S, Cosi V (2007) The N3 potential compared to sound and galvanic vestibular evoked myogenic potential in healthy subjects and in multiple sclerosis patients. J Vestib Res 17(1):39–46PubMedGoogle Scholar