Microvascular vasospasm of cerebral cortex in prolonged aura migraine
- 56 Downloads
Migraine is a very common and debilitating disorder. In 20% of cases, the migraine headache is preceded by an aura. The impairment of the cerebral and systemic arterial vascular system in migraine is well known. During migraine aura, some neuroimaging studies demonstrated reduction in cerebral blood flow (CBF). During attack of migraine with aura, a Transcranial Doppler (TCD) study suggests a cerebral hypoperfusion contralateral to the symptoms of aura .These condition may be due to an endothelial dysfunction. Many studies support the presence of endothelial dysfunction in migraineurs. The endothelial dysfunction is characterized by reduction in bioavailability of vasodilator (such as nitric oxide), increase in endothelial-derived contracting factors, and thus by a presence of vasoconstriction. It also comprises endothelial activation, characterized by a procoagulant, proinflammatory, and proliferative action, which, in addition, predispose to an increased rate of vascular...
Compliance with ethical standards
All procedures were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments. Informed consent was obtained from all individual participants included in the study.
Conflict of interest
The authors declare that they have no conflict of interest.