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Neurological Sciences

, Volume 39, Supplement 1, pp 95–96 | Cite as

Microvascular vasospasm of cerebral cortex in prolonged aura migraine

  • Stefano ViolaEmail author
  • Paolo Viola
  • Maria P. Buongarzone
  • Luisa Fiorelli
  • Mafalda Cipulli
  • Pasqualino Litterio
HEADACHE AND VASCULAR COMORBILITY

Migraine is a very common and debilitating disorder. In 20% of cases, the migraine headache is preceded by an aura. The impairment of the cerebral and systemic arterial vascular system in migraine is well known. During migraine aura, some neuroimaging studies demonstrated reduction in cerebral blood flow (CBF). During attack of migraine with aura, a Transcranial Doppler (TCD) study suggests a cerebral hypoperfusion contralateral to the symptoms of aura [1].These condition may be due to an endothelial dysfunction. Many studies support the presence of endothelial dysfunction in migraineurs. The endothelial dysfunction is characterized by reduction in bioavailability of vasodilator (such as nitric oxide), increase in endothelial-derived contracting factors, and thus by a presence of vasoconstriction. It also comprises endothelial activation, characterized by a procoagulant, proinflammatory, and proliferative action, which, in addition, predispose to an increased rate of vascular...

Notes

Compliance with ethical standards

All procedures were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments. Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare that they have no conflict of interest.

References

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    Aslan G, Sade LE, Yetis B, Bozbas H, Eroglu S, Pirat B, Can U, Muderrisoglu H (2013) Flow in the left anterior descending coronary artery in patients with migraine headache. Am J Cardiol 112:1540–1154CrossRefPubMedGoogle Scholar
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    Viola S, Viola P, Litterio P, Buongarzone MP, Fiorelli L (2012) Correlation between the arterial pulse wave of the cerebral microcirculation and CBF during breath holding and hyperventilation in human. Clin Neurophysiol 123:1931–1936CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  • Stefano Viola
    • 1
    Email author
  • Paolo Viola
    • 2
  • Maria P. Buongarzone
    • 1
  • Luisa Fiorelli
    • 1
  • Mafalda Cipulli
    • 1
  • Pasqualino Litterio
    • 1
  1. 1.Department of NeurologyHeadache CenterVastoItaly
  2. 2.Emergency Medical Service, AtessaLama dei PeligniItaly

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