Neurological Sciences

, Volume 39, Issue 5, pp 919–931 | Cite as

Aberrant default mode network in amnestic mild cognitive impairment: a meta-analysis of independent component analysis studies

  • ChunLei Wang
  • Yuan Pan
  • YanMei Liu
  • Ke Xu
  • LanXiang Hao
  • Fei Huang
  • Juan Ke
  • LiQin Sheng
  • HaiRong Ma
  • WeiFeng Guo
Original Article


Independent component analysis (ICA) is one of the most popular and valid methods to investigate the default mode network (DMN), an intrinsic network which attracts particular attention in amnestic mild cognitive impairment (aMCI). However, previous studies present inconsistent results regarding the topographical organization of the DMN in aMCI. Therefore, we conducted a quantitative, voxel-wise meta-analysis of resting-state ICA studies using Seed-based d Mapping to establish the most consistent pattern of DMN functional connectivity alterations in aMCI. Twenty studies, comprising 23 independent datasets involving 535 patients and 586 healthy controls, met the inclusion criteria. Patients with aMCI exhibited reliably lower DMN functional connectivity than the healthy controls in the bilateral precuneus/posterior cingulate cortices and medial temporal lobes, which are implicated in episodic memory deficits. Moreover, an exploratory meta-regression analysis revealed that greater severity of global cognitive impairment in the patient groups was associated with stronger functional connectivity in the bilateral medial frontal cortices (including the anterior cingulate cortices), left angular gyrus, and right temporal pole extending to the middle temporal gyrus, likely reflecting a compensatory mechanism for maintaining cognitive efficiency. This meta-analysis identifies a consistent pattern of aberrant DMN functional connectivity in aMCI, which facilitates understanding of the neurobiological substrates of this disease.


Amnestic mild cognitive impairment Default mode network Resting-state functional MRI Independent component analysis Seed-based d Mapping 



Alzheimer’s disease


amnestic mild cognitive impairment


anterior cingulate cortices


Auditory Verbal Learning Test


default mode network


full width at half maximum


independent component analysis


inferior parietal lobules


Montreal Neurological Institute


medial temporal lobe


Meta-analysis Of Observational Studies in Epidemiology


Mini-Mental State Examination


posterior cingulate cortices


Seed-based d Mapping


standardized mean difference


resting-state functional magnetic resonance imaging



We thank all the authors of the included studies.

Compliance with ethical standards

Conflicts of interests

The authors declare that they have no conflict of interest.

Supplementary material

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Supplementary Figure 1

(GIF 69 kb)

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High Resolution Image (TIFF 608 kb)
10072_2018_3306_MOESM2_ESM.docx (20 kb)
Supplementary Table 1 (DOCX 20 kb)


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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Encephalopathy Center, The First Clinical Medical CollegeNanjing University of Chinese MedicineNanjingPeople’s Republic of China
  2. 2.Department of EndocrinologyYancheng City No.1 People’s HospitalYanchengPeople’s Republic of China
  3. 3.Department of Radiology, Affiliated Yancheng Hospital, School of MedicineSoutheast UniversityYanchengPeople’s Republic of China
  4. 4.Department of NeurologyTraditional Chinese Medicine Hospital of KunshanKunshanPeople’s Republic of China

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