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Neurological Sciences

, Volume 39, Issue 5, pp 939–940 | Cite as

St. Catherine of Siena (1347–1380 AD): one of the earliest historic cases of altered gustatory perception in anorexia mirabilis

  • Francesco M. Galassi
  • Nicole BenderEmail author
  • Michael E. Habicht
  • Emanuele Armocida
  • Fabrizio Toscano
  • David A. Menassa
  • Matteo Cerri
Brief Communication

Abstract

St. Catherine of Siena suffered from an extreme form of holy fasting, a condition classified as anorexia mirabilis (also known as inedia prodigiosa). Historical and medical scholarships alike have drawn a comparison between this primaeval type of anorexia with a relatively common form of eating disorder among young women in the modern world, anorexia nervosa. St. Catherine’s condition was characterised by a disgust for sweet taste, a condition also described in anorexia nervosa, and characterised by specific neurophysiological changes in the brain. St. Catherine’s case may be considered one of the oldest veritable descriptions of altered gustation (dysgeusia). Moreover, a more compelling neurophysiological similarity between anorexia mirabilis and anorexia nervosa may be proposed.

Keywords

History of neurology Palaeopathology Anorexia Dysgeusia St. Catherine of Siena 

Notes

Acknowledgements

The authors wish to thank the Mäxi Foundation (Switzerland) for supporting this research.

Compliance with ethical standards

This article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Harris JC (2014) Anorexia nervosa and anorexia mirabilis: Miss K. R—and St Catherine of Siena. JAMA Psychiat 71(11):1212–1213CrossRefGoogle Scholar
  2. 2.
    Espi Forcen F, Espi Forcen C (2015) The practice of holy fasting in the late middle ages: a psychiatric approach. J Nerv Ment Dis 203(8):650–653CrossRefPubMedGoogle Scholar
  3. 3.
    Smink FRE, van Hoeken D, Hoek HW (2012) Epidemiology of eating disorders: incidence, prevalence and mortality rates. Curr Psychiatry Rep 14(4):406–414CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Davis AA, Nguyen M (2014) A case study of anorexia nervosa driven by religious sacrifice. Case Rep Psychiatry 2014:1–4CrossRefGoogle Scholar
  5. 5.
    Nocentini S (Ed.) Raimondo da Capua. Legenda Maior sive legenda admirabilis virginis Catherine de Senis. [Critical edition] Sismel. Edizioni del Galluzzo, Firenze, p 157Google Scholar
  6. 6.
    Galassi FM, Gelsi R (2015) Methodological limitations of an etiological framing of Ariarathes' goitre: response to Tekiner et al. J Endocrinol Investig 38(5):569CrossRefGoogle Scholar
  7. 7.
    Abe J, Hosokawa H, Okazawa M, Kandachi M, Sawada Y, Yamanaka K, Matsumura K, Kobayashi S (2005) TRPM8 protein localization in trigeminal ganglion and taste papillae. Brain Res Mol Brain Res 136(1–2):91–98CrossRefPubMedGoogle Scholar
  8. 8.
    Schoenfeld M, Neuer G, Tempelmann C, Schussler K, Noesselt T, Hopf J, Hopf JM (2004) Functional magnetic resonance tomography correlates of taste perception in the human primary taste cortex. Neuroscience 127:347–353CrossRefPubMedGoogle Scholar
  9. 9.
    Uher R, Murphy T, Brammer M, Dalgleish T, Phillips M, Ng VW Andrew CM, Williams SC, Campbell IC, Treasure J (2004) Medial prefrontal cortex activity associated with symptom provocation in eating disorders. Am J Psychiatry 161:1238–1246CrossRefPubMedGoogle Scholar
  10. 10.
    Oberndorfer TA, Frank GK, Simmons AN, Wagner A, McCurdy D, Fudge JL, Yang TT, Paulus MP, Kaye WH (2013) Altered insula response to sweet taste processing after recovery from anorexia and bulimia nervosa. Am J Psychiatry 170(10):1143–1151CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Chapman HA, Anderson AK (2012) Understanding disgust. Ann N Y Acad Sci 1251:62–76CrossRefPubMedGoogle Scholar
  12. 12.
    Vicario CM (2013) Altered insula response to sweet taste processing in recovered anorexia and bulimia nervosa: a matter of disgust sensitivity? Am J Psychiatry 170(12):1497–1497CrossRefPubMedGoogle Scholar
  13. 13.
    Halverson JL (2008) Contesting christendom: readings in medieval religion and culture. Rowman & Littlefield, p. 160Google Scholar

Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of Evolutionary MedicineUniversity of ZurichZurichSwitzerland
  2. 2.University of ParmaParmaItaly
  3. 3.Post-Graduate School of Public HealthUniversity of SienaSienaItaly
  4. 4.Nuffield Department of Clinical Neurosciences, Division of Clinical NeurologyUniversity of OxfordOxfordUK
  5. 5.Department of Biomedical and Neuromotor SciencesUniversity of BolognaBolognaItaly

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