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Neurological Sciences

, Volume 39, Issue 3, pp 557–564 | Cite as

Comparison of odor identification among amnestic and non-amnestic mild cognitive impairment, subjective cognitive decline, and early Alzheimer’s dementia

  • Sung-Jin Park
  • Jee-Eun Lee
  • Kwang-Soo Lee
  • Joong-Seok Kim
Original Article

Abstract

Olfactory impairment might be an important clinical marker and predictor of Alzheimer’s disease (AD). In the present study, we aimed to compare the degree of olfactory identification impairment in each mild cognitive impairment (MCI) subtype, subjective memory impairment, and early AD dementia and assessed the relationship between olfactory identification and cognitive performance. We consecutively included 50 patients with amnestic MCI, 28 patients with non-amnestic MCI, 20 patients with mild AD, and 17 patients with subjective memory impairment (SMI). All patients underwent clinical and neuropsychological assessments. A multiple choice olfactory identification cross-cultural smell identification test was also utilized. Controlling for age and gender, olfactory impairment was significantly more severe in patients with AD and amnestic MCI compared with the results from the non-amnestic MCI and SMI groups. Higher scores on MMSE, verbal and non-verbal memory, and frontal executive function tests were significantly related to olfactory identification ability. In conclusion, olfactory identification is impaired in amnestic MCI and AD. These findings are consistent with previous studies. In amnestic MCI patients, this dysfunction is considered to be caused by underlying AD pathology.

Keywords

Hyposmia Alzheimer’s disease Mild cognitive impairment Amnestic Non-amnestic Subjective memory impairment 

Supplementary material

10072_2018_3261_MOESM1_ESM.docx (19 kb)
ESM (DOCX 19 kb)

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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Neurology, College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

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