Rasagiline for dysexecutive symptoms during wearing-off in Parkinson’s disease: a pilot study
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Wearing-off refers to the predictable worsening of motor and sometimes non-motor symptoms of Parkinson’s disease occurring at the end of levodopa dose that improves with the next drug dose. Here, we investigated the efficacy of rasagiline on executive functions at the end of levodopa dose in patients displaying symptoms of wearing-off. Rasagiline was well-tolerated and produced a significant improvement at the Frontal Assessment Battery, together with improvement of motor symptoms at the end of levodopa dose. These results suggest that treatment of motor symptoms of wearing-off with rasagiline may be accompanied by improvement of executive functions, and further support the need for optimizing dopamine replacement therapy in fluctuating Parkinson’s disease patients.
KeywordsCognition Frontal Assessment Battery Parkinson’s disease Rasagiline Wearing-off
Supported by a research grant from Lundbeck to FEP
Compliance with ethical standards
This pilot study was approved by the local Ethical Committee, and each subject signed informed consent before enrollment.
Conflict of interest
FEP received honoraria for speaking at symposia from Abbvie and Zambon. The other authors have no conflict of interest to declare.
- 3.Hanagasi HA, Gurvit H, Unsalan P, Horozoglu H, Tuncer N, Feyzioglu A, Gunal DI, Yener GC, Cakmur R, Sahin HA, Emre M (2011) The effects of rasagiline on cognitive deficits in Parkinson’s disease patients without dementia: a randomized, double-blind, placebo-controlled, multicenter study. Mov Disord 26:1851–1858CrossRefPubMedGoogle Scholar
- 6.American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Publishing, WashingtonGoogle Scholar