Neurological Sciences

, Volume 38, Issue 12, pp 2223–2225 | Cite as

Wilson’s disease presenting as central pontine myelinolysis

  • Mahdi Safdarian
  • Renato P. Munhoz
  • Mahboubeh Aghaei
  • Mohammad RohaniEmail author
Letter to the Editor

Wilson’s disease (WD) is a rare autosomal recessive disease due to impaired biliary excretion of copper. Its main neurologic symptoms are dysarthria and movement disorders such as dystonia, tremor, and parkinsonism [1, 2]. Herein, we report a case of central pontine myelinolysis (CPM) presenting as an uncommon presentation of WD.

A 34-year-old woman in the third trimester of pregnancy was referred to our hospital because of acute onset quadriplegia, anarthria, and dysphagia, started 2 weeks prior to admission. According to her family, past medical history was unremarkable, except for long-standing mild upper extremities’ action tremor. Her pregnancy so far had been uneventful; there was no history of hyperemesis, vomiting, or use of medications. Family history of neurological diseases was negative. On neurologic examination, she was awake and alert but could only respond to questions with eye blinking. There was no ophthalmoplegia but saccadic eye movements were slow especially in...



Wilson’s disease


Central pontine myelinolysis


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Conflict of interest


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Financial disclosure


Supplementary material

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Supplementary Table 1 (DOCX 13 kb)
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Copyright information

© Springer-Verlag Italia S.r.l. 2017

Authors and Affiliations

  1. 1.Department of Neurology, Hazrat Rasool HospitalIran University of Medical SciencesTehranIran
  2. 2.Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson’s Disease, Toronto Western Hospital and Division of NeurologyUniversity of TorontoTorontoCanada

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