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Neurological Sciences

, Volume 38, Issue 10, pp 1741–1746 | Cite as

Mesencephalic astrocyte-derived neurotrophic factor and its role in nervous system disease

  • Zhu Li-na
  • Chen Deng
  • Xu Da
  • Chen Si-han
  • Wang Hai-jiao
  • Liu Ling
Review Article

Abstract

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a member of the novel evolutionary conserved neurotrophic factor (NTF) family. MANF has a unique structure and an unparalleled dual mode of action that differs from other known NTFs. Recent studies have shown that MANF protects cells from endoplasmic reticulum stress. In addition, an increasing number of studies have found MANF plays an important role in nervous system disease. This review focuses on MANF, summarizing its unique structure, potential signaling pathway, and role in neurological disease.

Keywords

NTF MANF Neurological disease 

Notes

Acknowledgements

The authors received no funding for this study.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Disclosure

Lina Zhu, Deng Chen, Xu Da, Sihan Chen, and Ling Liu have nothing to disclose. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

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Copyright information

© Springer-Verlag Italia S.r.l. 2017

Authors and Affiliations

  1. 1.Department of NeurologyWest China Hospital, Sichuan UniversityChengduChina

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