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Neurological Sciences

, Volume 38, Issue 10, pp 1893–1895 | Cite as

Dissecating aneurysm of extracranial internal carotid artery presenting with Tapia syndrome in patient with essential thrombocythemia

  • Alessandro IntronaEmail author
  • Luigi Chiumarulo
  • Marco Petruzzellis
Letter to the Editor

Dear Editor,

Cervical artery dissection (CAD) is a common cause of stroke in young and middle-aged patients, with an incidence of 2.6 per 100,000 inhabitants [1].

Different risk factors have been identified so far: trivial trauma, recent infections and inflammations, migraine, pregnancy and postpartum, vascular risk factors as hypertension and hyperhomocysteinemia, and connective tissue monogenic disease (Marfan’s syndrome, Ehlers-Danlos syndrome, osteogenesis imperfecta) [1].

However, growing evidences show structural predisposing conditions as underlying arteriopathy [2], kinking and coiling [3] of internal carotid artery (ICA) in spontaneous or trauma-induced CAD. Recently, rare copy number variants affecting arterial development other than monogenic connective disease have been proposed as endogenous cause of CAD [4]. Thus, the current hypothesis postulates that CAD is a multifactorial disorder with many exogenous and endogenous genetic factors responsible for wall arteries...

Notes

Authors’ contributions

Introna Alessandro: drafting the manuscript, study conception, interpretation of data, acquisition of data.

Chiumarulo Luigi: interpretation of data, acquisition of data

Petruzzellis Marco: critical revision of the manuscript for important intellectual content, study supervision

Compliance with ethical standards

All authors report no disclosures.

Informed consent was obtained from the patient included in the study. Additional informed consent was obtained to make video.

Supplementary material

Video 1

Tapia syndrome. (WMV 9670 kb)

References

  1. 1.
    Debette S, Leys D (2009) Cervical-artery dissections: predisposing factors, diagnosis, and outcome. Lancet Neurol 8:668–678CrossRefPubMedGoogle Scholar
  2. 2.
    Volker W, Dittrich R, Nassenstein I et al (2011) The outer arterial wall layers are primarily affected in spontaneous cervical artery dissection. Neurology 76:1463–1471CrossRefPubMedGoogle Scholar
  3. 3.
    Kim BJ, Yang E, Kim NY et al (2016) Vascular tortuosity may be associated with cervical artery dissection. Stroke 47:2548–2552CrossRefPubMedGoogle Scholar
  4. 4.
    Grond-Ginsbach C, Chen B, Krawczak M et al (2017) Genetic imbalance in patients with cervical artery dissection. Curr Genomics 18:206–213CrossRefPubMedGoogle Scholar
  5. 5.
    Marchetti M, Falanga A (2008) Leukocytosis, JAK2V617F mutation, and hemostasis in myeloproliferative disorders. Pathophysiol Haemost Thromb 36:148–159CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 2017

Authors and Affiliations

  1. 1.Neurology Unit, Department of Basic Medical Sciences, Neurosciences and Sense OrgansUniversity of Bari ‘Aldo Moro’BariItaly

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