Dissecating aneurysm of extracranial internal carotid artery presenting with Tapia syndrome in patient with essential thrombocythemia
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Cervical artery dissection (CAD) is a common cause of stroke in young and middle-aged patients, with an incidence of 2.6 per 100,000 inhabitants .
Different risk factors have been identified so far: trivial trauma, recent infections and inflammations, migraine, pregnancy and postpartum, vascular risk factors as hypertension and hyperhomocysteinemia, and connective tissue monogenic disease (Marfan’s syndrome, Ehlers-Danlos syndrome, osteogenesis imperfecta) .
However, growing evidences show structural predisposing conditions as underlying arteriopathy , kinking and coiling  of internal carotid artery (ICA) in spontaneous or trauma-induced CAD. Recently, rare copy number variants affecting arterial development other than monogenic connective disease have been proposed as endogenous cause of CAD . Thus, the current hypothesis postulates that CAD is a multifactorial disorder with many exogenous and endogenous genetic factors responsible for wall arteries...
Introna Alessandro: drafting the manuscript, study conception, interpretation of data, acquisition of data.
Chiumarulo Luigi: interpretation of data, acquisition of data
Petruzzellis Marco: critical revision of the manuscript for important intellectual content, study supervision
Compliance with ethical standards
All authors report no disclosures.
Informed consent was obtained from the patient included in the study. Additional informed consent was obtained to make video.
Tapia syndrome. (WMV 9670 kb)