Neurological Sciences

, Volume 38, Issue 7, pp 1307–1313 | Cite as

Association of arterial stiffness with cognition in patients with Lewy body disorder

  • Dong-Woo Ryu
  • Joong-Seok KimEmail author
  • Jee-Eun Lee
  • Jeong-Wook Park
  • Yoon-Sang Oh
  • Jae-Young An
  • Kwang-Soo LeeEmail author
Original Article


The brachial-ankle pulse wave velocity (baPWV) is a marker for arterial stiffness, which is associated with cardiovascular diseases. Arterial stiffness is associated with cognitive function in the elderly and patients with Alzheimer’s disease (AD). We aimed to investigate the association between arterial stiffness and cognitive function in patients with Lewy body disorder (LBD), including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). We consecutively included 123 patients with PD, 10 patients with DLB, and 27 AD controls. Patients with PD were divided into three groups of normal cognition (PD-NC, n = 63), mild cognitive impairment (PD-MCI, n = 43), and dementia (PD-D, n = 17). Arterial stiffness, measured as baPWV, was compared between the PD-NC, PD-MCI, PD-D, DLB, and AD patients. In LBD, we analyzed the association between arterial stiffness and each cognitive domain with adjustment for covariates. Higher baPWV was significantly associated with cognitive decline in patients with LBD (baPWV in PD-D > PD-MCI > PD-NC; DLB > PD-NC). There was no significant difference in baPWV between PD-D, DLB, and AD patients. In LBD patients, higher baPWV was associated with lower mini mental state examination score (β ± SE = −0.003 ± 0.001, p = 0.007) and more severe dementia. Higher baPWV was also associated with lower performance in attention, language, visuospatial function, memory, and executive function in LBD patients. This suggests that vascular brain injury is associated with cognitive dysfunction in LBD.


Arterial stiffness Pulse wave velocity Cognition Lewy body disorder 


Compliance with ethical standards

The study protocol was approved by the Institutional Review Board at Seoul St. Mary’s Hospital, and a waiver of consent was obtained for this Health Insurance Portability and Accountability Act-compliant retrospective study.

Conflict of interest

The authors declare that they have no competing interests.


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Copyright information

© Springer-Verlag Italia 2017

Authors and Affiliations

  1. 1.Department of Neurology, College of MedicineSeoul St. Mary’s Hospital, The Catholic University of KoreaSeoulRepublic of Korea

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