Neurological Sciences

, Volume 38, Supplement 1, pp 111–115 | Cite as

Ketogenic diet in migraine: rationale, findings and perspectives

  • Piero BarbantiEmail author
  • Luisa Fofi
  • Cinzia Aurilia
  • Gabriella Egeo
  • Massimiliano Caprio
Symposium - Nutraceutics and Headache


Ketogenic diet (KD) is an established treatment for refractory pediatric epilepsy and a promising therapy for diverse neurological diseases. Clinical data on KD in migraine—obtained from 150 patients investigated in case reports and prospective studies—suggest that KD may be a rapid onset effective prophylaxis for episodic and chronic migraine. KD would contribute to restore brain excitability and metabolism and to counteract neuroinflammation in migraine, although its precise mechanism is still unclear. Randomized controlled studies are needed to confirm the usefulness of KD in migraine and to investigate its optimal duration, repeatability, feasibility in normal weight subjects, efficacy in pediatric population and association to conventional migraine prophylaxis.


Migraine Ketogenic diet Treatment Prevention Disability 


Compliance with ethical standards

Conflict of interest

I certify that there is no actual or potential conflict of interest in relation to this article.


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Copyright information

© Springer-Verlag Italia 2017

Authors and Affiliations

  • Piero Barbanti
    • 1
    Email author
  • Luisa Fofi
    • 1
  • Cinzia Aurilia
    • 1
  • Gabriella Egeo
    • 1
  • Massimiliano Caprio
    • 2
    • 3
  1. 1.Headache and Pain Unit, Department of Neurological, Motor and Sensorial SciencesIRCCS San Raffaele PisanaRomeItaly
  2. 2.Laboratory of Cardiovascular EndocrinologyIRCCS San Raffaele PisanaRomeItaly
  3. 3.Department of Human Sciences and Promotion of the Quality of LifeSan Raffaele Roma Open UniversityRomeItaly

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