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Neurological Sciences

, Volume 38, Supplement 1, pp 173–175 | Cite as

Mindfulness and pharmacological prophylaxis have comparable effect on biomarkers of inflammation and clinical indexes in chronic migraine with medication overuse: results at 12 months after withdrawal

  • Licia GrazziEmail author
  • Domenico D’Amico
  • Alberto Raggi
  • Matilde Leonardi
  • Emilio Ciusani
  • Elena Corsini
  • Giovanni D’Andrea
  • Andrea Bolner
  • Francisco Salgado-García
  • Frank Andrasik
  • Emanuela Sansone
Brief Communication

Abstract

Chronic migraine (CM) is a disabling condition arising from a complex mixture of interconnected biological, psychological and social factors, and is often associated with medication overuse (MO). Mindfulness is emerging as a helpful treatment for pain, and one study showed that the longitudinal 12 months’ course of CM-MO patients that attended mindfulness-based treatment alone was similar to that of patients receiving medical prophylaxis alone; in this study, we describe the course of biomarkers of inflammation. Our results provide initial evidence of sustained similar effects on reduced concentration of biomarkers of inflammation, although not sizeable enough to reach statistical significance. Whether more intensive treatment and/or larger samples would lead to greater changes is unknown, but these encouraging preliminary findings suggest further research is warranted.

Keywords

Chronic migraine Medication overuse Mindfulness Biomarkers Interleukin-6 

Notes

Compliance with ethical standards

Conflict of interest

We certify that there is no actual or potential conflict of interest in relation to this article.

Ethical standards

The studies have been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and latest revisions (the latest in 2013). Patient informed consent to be included in the study has been obtained.

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Copyright information

© Springer-Verlag Italia 2017

Authors and Affiliations

  • Licia Grazzi
    • 1
    Email author
  • Domenico D’Amico
    • 1
  • Alberto Raggi
    • 2
  • Matilde Leonardi
    • 2
  • Emilio Ciusani
    • 3
  • Elena Corsini
    • 3
  • Giovanni D’Andrea
    • 4
  • Andrea Bolner
    • 4
  • Francisco Salgado-García
    • 5
  • Frank Andrasik
    • 5
  • Emanuela Sansone
    • 1
  1. 1.Headache and Neuroalgology UnitNeurological Institute “C. Besta” IRCCS FoundationMilanItaly
  2. 2.Neurology, Public Health and Disability UnitNeurological Institute “C. Besta” IRCCS FoundationMilanItaly
  3. 3.Laboratory of Clinical Pathology and Medical GeneticNeurological Institute “C. Besta” IRCCS FoundationMilanItaly
  4. 4.Research & Innovation (R&I)PaduaItaly
  5. 5.Department of PsychologyUniversity of MemphisMemphisUSA

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