Neurological Sciences

, Volume 38, Issue 5, pp 811–817 | Cite as

Serum levels of homocysteine at admission are associated with post-stroke depression in acute ischemic stroke

  • Yan Li
  • Li-Li Cao
  • Lin Liu
  • Qin-De Qi
Original Article


The primary purpose of this study was to assess the serum levels of homocysteine (HCY) at admission to the presence of post-stroke depression (PSD). From September 2014 to December 2015, first-ever acute ischemic stroke patients within the first 24 h after stroke onset were consecutively recruited and followed-up for 3 months. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression. By the time of 3 month after stroke, 238 had finished the follow-up and included in our study. Totally, 65 out of the 238 patients were diagnosed as depression (27.3%; 95% CI 19.6–35.4%). The results showed significantly higher HCY levels in patients with depression [21.4 (IQR 16.5–23.4) mmol/L vs. 14.1 (IQR 11.2–18.5) mmol/L, P < 0.0001) at admission than patients without depression. In multivariate logistic regression analysis, HCY was an independent predictor of PSD with an adjusted OR of 1.07 (95% CI 1.01–1.22; P = 0.013). Based on the ROC curve, the optimal cut-off value of serum HCY levels as an indicator for prediction of PSD was projected to be 16.5 mmol/L, which yielded a sensitivity of 82.5% and a specificity of 63.6%, with the area under the curve at 0.745 (95% CI 0.672–0.818; P < 0.0001). An increased risk of PSD was associated with serum HCY levels ≥16.5 mmol/L (adjusted OR 6.13, 95% CI 3.32–14.16; P < 0.001) after adjusting for above-recorded confounders. Elevated serum levels of HCY at admission were associated with depression 3-month after stroke, suggesting that these alterations might participate in the pathophysiology of depression symptoms in stroke patients.


Homocysteine Stroke Depression Chinese 



We also express our gratitude to all the patients, the nurses and physicians who participated in this study, and thereby made this work possible.

Compliance with ethical standards

Conflict of interest



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Copyright information

© Springer-Verlag Italia 2017

Authors and Affiliations

  1. 1.Department of NeurologyQilu Hospital of Shandong UniversityJinanPeople’s Republic of China
  2. 2.Department of NeurologyThe People’s Hospital of Laiwu CityLaiwuPeople’s Republic of China

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