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Repeated sessions of transcranial direct current stimulation evaluation on fatigue and daytime sleepiness in Parkinson’s disease

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Abstract

Parkinson is a common and disabling disease that affects patient’s and career’s quality of life. Unfortunately, medications, such as dopaminergic and sedative-hypnotic drugs, as an effective treatment have unwilling side effects. Recently, Transcranial Direct Current Stimulation (tDCS) in conjunction with medication becomes popular as a complementary safe treatment and several studies have proved its effectiveness on controlling motor and specially non-motor aspects of Parkinson’s disease. In this randomized double-blind parallel study, 23 patients with Parkinson’s disease divided into two groups of real tDCS plus occupational therapy and sham tDCS plus occupational therapy and the effects of therapeutic sessions (eight sessions tDCS with 0.06 mA/cm2 current, 20 min on dorsolateral prefrontal cortex) were evaluated on fatigue and daytime sleepiness just after therapeutic course and in 3-month follow-up. tDCS had a significant effect on fatigue and no effect on daytime sleepiness reduction in patients with Parkinson’s disease. tDCS is an effective and safe complementary treatment on fatigue reduction in Parkinson’s disease.

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Acknowledgements

We are grateful to patients who participated in this project and Pouria Ghaboussi, MD for his help in identification of treatment protocol.

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Authors and Affiliations

  1. Neuromusculoskeletal Research Center, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran

    Bijan Forogh, Maryam Rafiei, Amin Arbabi & Seyed Pezhman Madani

  2. Department of Neurology, Firoozgar hospitalIran University of Medical Sciences, Tehran, Islamic Republic of Iran

    Mohammad Reza Motamed

  3. Burn Research Center, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran

    Simin Sajadi

Authors
  1. Bijan Forogh
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  2. Maryam Rafiei
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  3. Amin Arbabi
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  4. Mohammad Reza Motamed
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  5. Seyed Pezhman Madani
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  6. Simin Sajadi
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Correspondence to Simin Sajadi.

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Forogh, B., Rafiei, M., Arbabi, A. et al. Repeated sessions of transcranial direct current stimulation evaluation on fatigue and daytime sleepiness in Parkinson’s disease. Neurol Sci 38, 249–254 (2017). https://doi.org/10.1007/s10072-016-2748-x

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  • DOI: https://doi.org/10.1007/s10072-016-2748-x

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