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Neurological Sciences

, Volume 37, Issue 11, pp 1853–1855 | Cite as

Rapidly progressive neurological deterioration in anti-AMPA receptor encephalitis with additional CRMP5 antibodies

  • Shuangshuang Yang
  • Jie Qin
  • Jinghong Li
  • Yuan Gao
  • Lu Zhao
  • Jun Wu
  • Bo Song
  • Yuming Xu
  • Shilei SunEmail author
Brief Communication

Abstract

Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) encephalitis positive for additional onconeural antibodies is rarely reported. Here we report the clinical features of a patient who developed limbic encephalitis with both glutamate receptor 2 (GluR2) and collapsin response mediator protein 5 (CRMP5) antibodies. Brain magnetic resonance imaging revealed multifocal encephalopathy. Chest computed tomography showed a highly suspicious malignant thymoma. He experienced rapid neurological deterioration during hospitalization. This report indicates that the clinical diversity of anti-AMPAR encephalitis and the presence of onconeural antibodies may lead to poor prognosis.

Keywords

Autoimmune Encephalitis AMPAR CRMP5 Antibodies Thymoma 

Notes

Acknowledgments

This study was supported by grant from Natural Science Foundation of China (No. 81301007 to Jie Qin).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Italia 2016

Authors and Affiliations

  • Shuangshuang Yang
    • 1
  • Jie Qin
    • 1
  • Jinghong Li
    • 1
  • Yuan Gao
    • 1
  • Lu Zhao
    • 1
  • Jun Wu
    • 1
  • Bo Song
    • 1
  • Yuming Xu
    • 1
  • Shilei Sun
    • 1
    Email author
  1. 1.Department of NeurologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

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