Neurological Sciences

, Volume 37, Issue 11, pp 1779–1784 | Cite as

Effects of onabotulinumtoxinA treatment on efficacy, depression, anxiety, and disability in Turkish patients with chronic migraine

  • Bekir Enes Demiryurek
  • Devrimsel Harika Ertem
  • Atilla Tekin
  • Mustafa Ceylan
  • Yesim Guzey Aras
  • Belma Dogan Gungen
Original Article

Abstract

Chronic migraine causes a serious labour loss and disability in the society and increases the risk of depression and anxiety by negatively affecting the quality of life. The purpose of this study was to investigate the effects of onabotulinumtoxinA (BoNT-A) treatment on efficacy before and after treatment in our cases with chronic migraine as well as on depression, anxiety and disability caused by migraine. According to the International Headache Classification (ICHD-III beta version), 60 adult patients who were diagnosed with chronic migraine were included in the study. A total of 155 IU BoNT-A treatment from 31 regions was administered in accordance with the protocol of PREEMPT study. Information about the characteristics of patients’ headaches, background and family history, drugs they used was recorded. At the baseline and in the first and third month after the BoNT-A injection, VAS scores, the number of both headache days and attacks, the headache duration, the frequency of application to emergency services and the intake of both analgesics and triptans during attacks were evaluated. MIDAS, BDI and BAI were evaluated at the baseline and in the third month after the BoNT-A injection. BoNT-A injection provided a significant decrease in the number of days and severity of headaches, MIDAS disability scores and psychiatric complaints in cases with chronic migraine who did not respond to prophylactic treatments in the third month of the treatment.

Keywords

OnabotulinumtoxinA Chronic migraine Prophylactic treatment Disability Depression Anxiety 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Italia 2016

Authors and Affiliations

  • Bekir Enes Demiryurek
    • 1
  • Devrimsel Harika Ertem
    • 2
  • Atilla Tekin
    • 3
  • Mustafa Ceylan
    • 4
  • Yesim Guzey Aras
    • 1
  • Belma Dogan Gungen
    • 1
  1. 1.Neurology DepartmentSakarya University Education and Research HospitalSakaryaTurkey
  2. 2.Algology DepartmentIstanbul University Cerrahpasa Medical FacultyIstanbulTurkey
  3. 3.Psychiatri DepartmentAbant Izzet Baysal University Psychiatri Education and Research HospitalBoluTurkey
  4. 4.Neurology DepartmentErzurum Regional Training and Research HospitalErzurumTurkey

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