Neurological Sciences

, Volume 37, Issue 10, pp 1693–1700 | Cite as

Subclinical change of liver function could also provide a clue on prognosis for patients with spontaneous intracerebral hemorrhage

  • Ge Tan
  • Zilong Hao
  • Chunyan Lei
  • Yanchao Chen
  • Ruozhen Yuan
  • Mangmang Xu
  • Ming LiuEmail author
Original Article


Whether subclinical change of liver function is associated with outcome of spontaneous intracerebral hemorrhage remains to be an open question. A total of 639 patients of spontaneous intracerebral hemorrhage within 7 days from stroke onset were finally enrolled. Liver function indicators, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin (BIL), alkaline phosphatase (ALP), gamma glutamyl transpeptidase (GGT), albumin (ALB), and international normalized ratio (INR), were collected and collapsed into quartiles. The main outcomes were 30-day death, 90-day death, and 90-day poor outcome (modified Rankin Scale score of 3–6). Two adjusted model, Model 1 and Model 2 (Model 1 plus GCS score), were established to identify independent association between liver function indicators and ICH outcomes. The mortality rate was 19.9 % (127/639) at 30 days and 21.3 % (136/639) at 90 days. Rate of 90-day poor outcome was 51.5 % (329/639). Among liver function indicators, AST and ALP were associated with all the three outcomes, which did not alter significantly when adjusted by Model 1. After adjusted by Model 2, ALP was still associated with outcomes. Association between AST and outcomes was, however, weakened significantly by GCS score. In conclusions, among liver function indicators, AST and ALP were associated with outcomes after spontaneous intracerebral hemorrhage.


Intracerebral hemorrhage Outcome Risk factor Liver function 



This study was supported by the National Key Technology R&D Program for the 12th Five-Year Plan of People’s Republic of China (2011BAI08B05).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Supplementary material

10072_2016_2656_MOESM1_ESM.docx (16 kb)
Supplementary material 1 (DOCX 16 kb)


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Copyright information

© Springer-Verlag Italia 2016

Authors and Affiliations

  • Ge Tan
    • 1
  • Zilong Hao
    • 1
  • Chunyan Lei
    • 1
  • Yanchao Chen
    • 1
  • Ruozhen Yuan
    • 1
  • Mangmang Xu
    • 1
  • Ming Liu
    • 1
    Email author
  1. 1.Stroke Clinical Research Unit, Department of Neurology, West China HospitalSichuan UniversityChengduPeople’s Republic of China

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