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Neurological Sciences

, Volume 37, Issue 10, pp 1749–1750 | Cite as

Unilateral isolated oculomotor nerve palsy with antibodies to GM1 ganglioside

  • Dokyung Lee
  • Jun-Hyun Kim
  • Jae-Hong Lee
  • Boo Suk Na
  • Sung Sang YoonEmail author
Letter to the Editor
  • 128 Downloads

Dear editor,

Acute unilateral oculomotor nerve palsy is generally caused by either structural lesions, such as tumors, in the orbit, cavernous sinus, or subarachnoid space of the brain stem, or cerebrovascular disorders including posterior communicating artery aneurysm [1]. Oculomotor nerve palsy is commonly associated with variant type Guillain–Barre Syndrome (GBS). Although ophthalmoplegia can occur in the absence of limb symptoms, the vast majority of ophthalmoplegia in variant type GBS affects multiple cranial nerves (multiple cranial neuropathy) and often both eyes [2]. Here, we report a case with unilateral oculomotor nerve palsy associated with antibodies to ganglioside GM1 (anti-GM1 antibody) without other causes.

A 69-year-old woman presented to our hospital with symptoms of double vision, ptosis, and mild left orbital pain, which had developed in the past 2 days. The patient also reported symptoms of fatigue and numbness on the medial surface of both forearms, which had...

Keywords

Ophthalmoplegia Multifocal Motor Neuropathy Oculomotor Nerve Palsy Painful Ophthalmoplegia Posterior Communicate Artery Aneurysm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Compliance with ethical standards

Conflict of interest

None.

Supplementary material

Supplementary material 1 (WMV 14725 kb) Video 1. This video was taken after steroid therapy (6th day after onset of ophthalmoplegia). Complete ptosis of the left eyelid is noted. Limitations are evident in the up, down, and medial gaze of the left eyeball. The movement of right eyeball is normal. The patient gave written permission for the publication of her clinical data and video

References

  1. 1.
    Chou KL, Galetta SL, Liu GT, Volpe NJ, Bennett JL, Asbury AK et al (2004) Acute ocular motor mononeuropathies: prospective study of the roles of neuroimaging and clinical assessment. J Neurol Sci 219(1–2):35–39CrossRefPubMedGoogle Scholar
  2. 2.
    Odaka M, Yuki N, Hirata K (2001) Anti-GQ1b IgG antibody syndrome: clinical and immunological range. J Neurol Neurosurg Psychiatry 70(1):50–55CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Rigamonti A, Lauria G, Longoni M, Stanzani L, Agostoni E (2011) Acute isolated ophthalmoplegia with anti-GQ1b antibodies. Neurol Sci 32(4):681–682CrossRefPubMedGoogle Scholar
  4. 4.
    Lavallee P, Vidailhet M, Dussaule JC, Derkinderen P (2001) Post-infectious ophtalmoparesis associated with anti-GM1 but not with anti-GQ1b antibodies. Eur J Neurol 8(5):475–476CrossRefPubMedGoogle Scholar
  5. 5.
    Go T (2000) Partial oculomotor nerve palsy associated with elevated anti-galactocerebroside and anti-GM1 antibodies. J Pediatr 137(3):425–426CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 2016

Authors and Affiliations

  • Dokyung Lee
    • 1
  • Jun-Hyun Kim
    • 2
  • Jae-Hong Lee
    • 1
  • Boo Suk Na
    • 1
  • Sung Sang Yoon
    • 1
    Email author
  1. 1.Department of Neurology, College of MedicineKyung Hee UniversitySeoulRepublic of Korea
  2. 2.Department of NeurologyGurosungsim HospitalSeoulRepublic of Korea

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