Perihaematomal cytokine expression is a crucial component of intracerebral haemorrhage pathophysiology
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The activation of nuclear factor-kappa B (NF-κB) is a central molecular event in the pathophysiology of intracerebral haemorrhage (ICH). The recent report by Zhang et al.  has provided us with a detailed account of the time-dependent expression patterns of major (NF-κB-activated), pro-inflammatory cytokines (tumour necrosis factor-alpha and interleukin-1beta; TNF-α and IL-1β, respectively) in clinical samples obtained from basal ganglia ICH patients and appropriately selected controls. The immunohistochemical analysis of the perihaematomal regions (PHRs; also known as “perihaematomal penumbra”) of these patients has reconfirmed the central role of NF-κB in triggering the so-called “secondary damage” of ICH, which seems to correlate well with the occurring cell death .
KeywordsGlial Fibrillary Acidic Protein Neuronal Loss Intracerebral Haemorrhage Cytokine Expression Vasogenic Oedema
This work was supported by the Wellcome Trust [096978/Z/11/Z].
Conflict of interest
There are no conflicts of interest.
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