Neurological Sciences

, Volume 35, Issue 7, pp 1053–1058

Quality of life in patients with craniocervical dystonia: Italian validation of the “Cervical Dystonia Impact Profile (CDIP-58)” and the “Craniocervical Dystonia Questionnaire (CDQ-24)”

  • Margherita Fabbri
  • Maria Superbo
  • Giovanni Defazio
  • Cesa Lorella Maria Scaglione
  • Elena Antelmi
  • Giacomo Basini
  • Stefania Nassetti
  • Fabio Pizza
  • Rosaria Plasmati
  • Rocco Liguori
Original Article

Abstract

Dystonia is a disabling and disfiguring disorder that can often affect many aspects of patients’ daily lives, and lower their self-esteem. To date, quality of life (QoL) has been assessed in dystonic patients using generic measures that do not address the specific problems of this diagnostic group. Recently, two disease-specific scales “The Cervical Dystonia Impact Profile (CDIP-58)” and the “Craniocervical Dystonia Questionnaire (CDQ-24)” were validated for measuring QoL in craniocervical dystonia patients. No disease-specific scales for QoL for dystonic patients are currently available in Italian. The aim of our study was to produce and validate the Italian version of the CDIP-58 and CDQ-24. We obtained the Italian version of CDQ-24 and CDIP-58 with a back-translation design. Both scales were applied to a population of 94 craniocervical dystonia patients along with the Short Form 36 health-survey questionnaire (SF-36), both before and 4 weeks after botulinum toxin therapy. A group of 65 controls matched for sex, age and comorbidity underwent the SF-36. Internal consistency was satisfactory for all subscales. Both the CDIP-58 and CDQ-24 showed moderate to high correlations with similar items of the SF-36. Sensitivity to change was confirmed by highly significant improvements in all CDQ-24 subscales and by moderate improvements in three out of eight CDIP-58 subscales and total score. This is the first Italian study on QoL in dystonia patients. We validated the Italian version of two disease-specific questionnaires to evaluate QoL in craniocervical dystonia patients. These scales could be useful for both clinical practice and clinical trials.

Keywords

Quality of life CDQ-24 CDIP-58 Craniocervical dystonia 

Supplementary material

10072_2014_1642_MOESM1_ESM.doc (57 kb)
Table S1. Correlation coefficients. Correlation coefficient results between the SF-36 items and the CDIP-58 and CDQ-24 items. Asterisks * indicates significant statistical correlations. The single items of each scale are indicated in Arabic numbers (DOC 57 kb)
10072_2014_1642_MOESM2_ESM.doc (78 kb)
Appendix 1. CDIP-58 (I). Supplementary material 2 (DOC 78 kb)
10072_2014_1642_MOESM3_ESM.doc (28 kb)
Appendix 2. CDQ-24 (I) Supplementary material 3 (DOC 27 kb)

Copyright information

© Springer-Verlag Italia 2014

Authors and Affiliations

  • Margherita Fabbri
    • 1
    • 2
  • Maria Superbo
    • 3
  • Giovanni Defazio
    • 3
  • Cesa Lorella Maria Scaglione
    • 1
  • Elena Antelmi
    • 1
    • 2
  • Giacomo Basini
    • 1
  • Stefania Nassetti
    • 1
  • Fabio Pizza
    • 1
    • 2
  • Rosaria Plasmati
    • 1
  • Rocco Liguori
    • 1
    • 2
  1. 1.IRCCS Institute of Neurological SciencesBolognaItaly
  2. 2.Department of Biomedical and NeuroMotor Sciences (DIBINEM), Alma Mater StudiorumUniversity of BolognaBolognaItaly
  3. 3.Department of Neuroscience and Sensory Organs‘Aldo Moro’ University of BariBari 2Italy

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