Hemichorea in a thymoma patient without anti-CRMP-5 antibody
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We reported a 72-year-old man with thymoma who presented with hemichorea. Although his brain CT and MRI revealed no abnormality, regional cerebral blood flow changes, identified by single photon emission computed tomography, suggested that the mechanism underlying the chorea seemed to be a dysfunction of the subthalamic nucleus and pallidum. His hemichorea was completely resolved after thymectomy. Absence of serum anti-neural autoantibodies, including small-cell lung carcinoma-related chorea anti-CRMP-5 antibody, suggests that mechanisms different from cross-talk neural-targeted tumor immune response can be responsible for the thymoma-associated paraneoplastic chorea.
KeywordsParaneoplastic chorea Hemichorea Thymoma Anti-CRMP-5 antibody
We express our gratitude to Professor Keiko Tanaka, Department of Neurology, Kanazawa Medical University, for measurement of neuronal autoantibodies in this case.
Conflict of interest
The authors have no conflict of interest to declare.
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- 4.Honnorat J, Cartalat-Carel S, Ricard D, Camdessanche JP, Carpentier AF, Rogemond V, Chapuis F, Aguera M, Decullier E, Duchemin AM, Graus F, Antoine JC (2009) Onco-neural antibodies and tumour type determine survival and neurological symptoms in paraneoplastic neurological syndromes with Hu or CV2/CRMP5 antibodies. J Neurol Neurosurg Psychiatry 80:412–416PubMedCentralPubMedCrossRefGoogle Scholar