Neurological Sciences

, Volume 35, Issue 4, pp 629–630 | Cite as

Hemichorea in a thymoma patient without anti-CRMP-5 antibody

  • Yoshiharu NakaeEmail author
  • Shingo Ikeda
  • Ryoo Yamamoto
  • Fumiaki Tanaka
  • Ken Johkura
Letter to the Editor


We reported a 72-year-old man with thymoma who presented with hemichorea. Although his brain CT and MRI revealed no abnormality, regional cerebral blood flow changes, identified by single photon emission computed tomography, suggested that the mechanism underlying the chorea seemed to be a dysfunction of the subthalamic nucleus and pallidum. His hemichorea was completely resolved after thymectomy. Absence of serum anti-neural autoantibodies, including small-cell lung carcinoma-related chorea anti-CRMP-5 antibody, suggests that mechanisms different from cross-talk neural-targeted tumor immune response can be responsible for the thymoma-associated paraneoplastic chorea.


Paraneoplastic chorea Hemichorea Thymoma Anti-CRMP-5 antibody 



We express our gratitude to Professor Keiko Tanaka, Department of Neurology, Kanazawa Medical University, for measurement of neuronal autoantibodies in this case.

Conflict of interest

The authors have no conflict of interest to declare.

Supplementary material

10072_2014_1629_MOESM1_ESM.doc (42 kb)
Supplementary material 1 (DOC 41 kb)

Supplementary material 2 (MPG 4323 kb)

Supplementary material 3 (MPG 4148 kb)


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Copyright information

© Springer-Verlag Italia 2014

Authors and Affiliations

  • Yoshiharu Nakae
    • 1
    Email author
  • Shingo Ikeda
    • 1
  • Ryoo Yamamoto
    • 1
  • Fumiaki Tanaka
    • 2
  • Ken Johkura
    • 1
  1. 1.Department of NeurologyHiratsuka Kyosai HospitalHiratsukaJapan
  2. 2.Department of Neurology and Stroke MedicineYokohama City University Graduate School of MedicineYokohamaJapan

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