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Neurological Sciences

, Volume 35, Issue 2, pp 327–329 | Cite as

Clinical and neuropathological findings in Hashimoto’s encephalopathy: a case report

  • Daniele ImperialeEmail author
  • Carmelo Labate
  • Roberto Testi
  • Alessandra Romito
  • Stefano Taraglio
Letter to the Editor

Dear Sir,

Hashimoto’s encephalopathy (HE) is a controversial autoimmune condition of the central nervous system (CNS) characterized by focal and/or diffuse symptoms concomitant with raised levels of anti-thyroid antibodies, in particular anti-thyroperoxidase (TPO) and/or anti-thyroglobulin (TG) antibodies [1]. Hereby, we provide the full clinical and neuropathological description of an HE patient with a rapid and fatal course.

A 67-year-old man with autoimmune hypothyroidism taking l-thyroxine 100 μg/day came to our observation because of 1-month history of apathy and speech difficulties. At admission in the neurological ward, fluent aphasia, disorientation, and spontaneous diffuse myoclonic jerks were present. Cranial CT and brain MRI were unremarkable. EEG evidenced rare diffuse theta-delta bursts. On laboratory investigations, we detected only a markedly raised titer of serum anti-TPO antibodies (3,790 UI/ml). CSF analysis disclosed very high protein concentration (126 mg/dL) with...

Keywords

Prion Disease Hippocampal Sclerosis Refractory Status Epilepticus Neurological Paraneoplastic Syndrome Convulsive Status Epilepticus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  • Daniele Imperiale
    • 1
    Email author
  • Carmelo Labate
    • 2
  • Roberto Testi
    • 1
  • Alessandra Romito
    • 1
  • Stefano Taraglio
    • 1
  1. 1.Centro Regionale Diagnosi ed Osservazione Malattie Prioniche DOMP, ASL To2TurinItaly
  2. 2.S.C. Neurologia Ospedale Umberto I, ASO MaurizianoTurinItaly

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