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Neurological Sciences

, Volume 34, Issue 11, pp 2015–2022 | Cite as

Adherence to anti-Parkinson drug therapy in the “REASON” sample of Italian patients with Parkinson’s disease: the linguistic validation of the Italian version of the “Morisky Medical Adherence scale-8 items”

  • G. Fabbrini
  • G. Abbruzzese
  • P. Barone
  • A. Antonini
  • M. Tinazzi
  • G. Castegnaro
  • S. Rizzoli
  • D. E. Morisky
  • P. Lessi
  • R. Ceravolo
  • On behalf of the REASON study group
Original Article

Abstract

Information about patients’ adherence to therapy represents a primary issue in Parkinson’s disease (PD) management. To perform the linguistic validation of the Italian version of the self-rated 8-Item Morisky Medical Adherence Scale (MMAS-8) and to describe in a sample of Italian patients affected by PD the adherence to anti-Parkinson drug therapy and the association between adherence and some socio-demographic and clinical features. MMAS-8 was translated into Italian language by two independent Italian mother-tongue translators. The consensus version was then back-translated by an English mother-tongue translator. This translation process was followed by a consensus meeting between the authors of translation and investigators and then by two comprehension tests. The translated version of the MMAS-8 scale was then administered at the baseline visit of the “REASON” study (Italian Study on the Therapy Management in Parkinson’s disease: Motor, Non-Motor, Adherence and Quality Of Life Factors) in a large sample of PD patients. The final version of the MMAS-8 was easily understood. Mean ± SD MMAS-8 score was 6.1 ± 1.2. There were no differences in adherence to therapy in relationship to disease severity, gender, educational level or decision to change therapy. The Italian version of MMAS-8, the key tool of the REASON study to assess the adherence to therapy, has shown to be understandable to patients with PD. Patients enrolled in the REASON study showed medium therapy adherence.

Keywords

Adherence Parkinson’s disease Validation Comprehension 

Abbreviations

APD

Anti-Parkinson drug

HY

Hoehn and Yahr

MMAS-4

4-Item Morisky Medical Adherence Scale

MMAS-8

8-Item Morisky Medical Adherence Scale

PD

Parkinson’s disease

Notes

Acknowledgments

The authors meet the criteria for authorship as recommended by the International Committee of Medical Journal Editors (ICMJE) and were fully responsible for all aspects of manuscript development. We are grateful to MediData (Modena, Italy) for data collection and statistical analysis. This research was sponsored by a grant from Boehringer-Ingelheim.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  • G. Fabbrini
    • 1
  • G. Abbruzzese
    • 2
  • P. Barone
    • 3
  • A. Antonini
    • 4
  • M. Tinazzi
    • 5
  • G. Castegnaro
    • 6
  • S. Rizzoli
    • 6
  • D. E. Morisky
    • 7
  • P. Lessi
    • 8
  • R. Ceravolo
    • 9
  • On behalf of the REASON study group
  1. 1.Sapienza University of Rome and IRCCS Neuromed InstitutePozzilli (IS)Italy
  2. 2.Neurosciences, Ophthalmology and Genetics DepartmentUniversity of GenovaGenoaItaly
  3. 3.Schola Medica SalernitanaUniversity of SalernoSalernoItaly
  4. 4.Department for Parkinson’s DiseaseIRCCS San CamilloVeniceItaly
  5. 5.Department of Neurological, Neuropsychological, Morphological and Movement SciencesUniversity of VeronaVeronaItaly
  6. 6.Medidata, Studi e RicercheModenaItaly
  7. 7.Department of Community Health SciencesUCLA Fielding School of Public HealthLos AngelesUSA
  8. 8.Boehringer-Ingelheim Italia S.p.A, Medical Clinical OperationMilanItaly
  9. 9.Neurosciences DepartmentUniversity of PisaPisaItaly

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