A pediatric case of Miller Fisher syndrome with central involvement
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Miller Fisher syndrome (MFS) is a rare condition characterized by external ophthalmoplegia, ataxia, and areflexia, and is considered a clinical variant of Guillain-Barré syndrome (GBS). Reports on MFS with Bickerstaff brainstem encephalitis (BBE) overlapping are also reported and a clear distinction between the two disorders is still debated . Nevertheless, both clinical pictures are characterized in up to 90 % of cases by high titre of serum anti GQ1b antibodies, which have a clear pathogenetic role.
We describe a rare case of pediatric MFS with clinical central involvement, and a good recovery after the second cycle of intravenous immunoglobulin (IVIg), suggesting a therapeutic efficacy of immunomodulatory treatment.
A six-year-old child was referred to our Hospital for acute onset of diplopia, left palpebral ptosis and sixth left nerve palsy associated to gait ataxia. The day after, the patient worsened with drowsiness, ophthalmoplegia, dysphagia and...
KeywordsMuscle Spindle Ophthalmoplegia Somatosensory Evoke Potential Miller Fisher Syndrome Central Involvement
- 2.Fargas i Busquets A, Roig Quilis M, Gratacòs Vinyola M, Macaya Ruiz A, Del Toro Riera M, Fitó Costa A (1998) Ophthalmoplegia-ataxia-areflexia in pediatrics. Three new patients and review of the literature. An Esp Pediatr 48:483–488Google Scholar