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Neurological Sciences

, Volume 34, Issue 5, pp 679–682 | Cite as

TLR91237 T/C and TLR2194 to174 del polymorphisms and the risk of Parkinson’s disease in the Greek population: a pilot study

  • Kallirhoe Kalinderi
  • Sevasti Bostantjopoulou
  • Zoe Katsarou
  • Liana Fidani
Original Article

Abstract

Toll-like receptors (TLRs) are important mediators of inflammatory responses by recognition of many pathogen-related molecules and endogenous proteins related to immune activation. Accumulating data have recently pointed out the role of neuroinflammation in Parkinson’s disease (PD) pathogenesis. In the present study, we investigated the potential role of the TLR91237 T/C and TLR2194 to174 del polymorphisms in PD. We studied a total of 333 individuals, 215 Greek patients with sporadic PD and 118 control subjects, using a polymerase chain reaction–restriction fragment length polymorphism method. No statistically significant differences were found between PD patients and control subjects for the TLR91237 T/C genotypes or alleles. Regarding the TLR2196 to174 del polymorphism, the del/del genotype and the del allele were overrepresented in the PD group compared to controls, however, this result did not reach statistical significance (P = 0.087). Further studies investigating the TLR-inflammatory background of PD are awaited to provide important insight into the aetiology of the disease.

Keywords

Parkinson’s disease Toll-like receptors Polymorphism 

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Kallirhoe Kalinderi
    • 1
  • Sevasti Bostantjopoulou
    • 2
  • Zoe Katsarou
    • 2
  • Liana Fidani
    • 1
  1. 1.Department of General BiologyMedical School, Aristotle University of ThessalonikiThessalonikiGreece
  2. 2.Third Department of NeurologyG. Papanikolaou Hospital, Aristotle University of ThessalonikiThessalonikiGreece

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