Neurological Sciences

, Volume 33, Supplement 1, pp 37–41 | Cite as

Migraine: risk factor and comorbidity

MIGRAINE AS A RISK FACTOR

Abstract

The burden of migraine strongly increases considering its linkage with other psychiatric, neurological, cardiovascular and cerebrovascular diseases. Migraine is positively associated with many disorders: some are confirmed by several studies whereas others remain uncertain or controversial. The association with some disorders is not simply due to concomitance but it implies a linkage in terms of causality. Highlighting these relationships is important to improve treatment strategies, broaden our knowledge of the pathophysiology and understand if migraine is per se a modifiable risk factor for some disorders.

Keywords

Migraine Comorbidity Risk factor 

References

  1. 1.
    Jensen R, Stovner LJ (2008) Epidemiology and comorbidity of headache. Lancet Neurol 7:354–361PubMedCrossRefGoogle Scholar
  2. 2.
    Wang SJ, Chen PK, Fuh JL (2010) Comorbidities of migraine. Front Neurol 1:1–9Google Scholar
  3. 3.
    Cannon PR, Larner AJ (2011) Migraine and restless legs syndrome: is there an association? J Headache Pain 12:405–409PubMedCrossRefGoogle Scholar
  4. 4.
    Antonaci F, Nappi G, Galli F, Manzoni GC, Calabresi P, Costa A (2011) Migraine and psychiatric comorbidity: a review of clinical findings. J Headache Pain 12:115–125PubMedCrossRefGoogle Scholar
  5. 5.
    Baskin SM, Smitherman TA (2009) Migraine and psychiatric disorders: comorbidities, mechanism, and clinical applications. Neurol Sci 30(Suppl 1):S61–S65PubMedCrossRefGoogle Scholar
  6. 6.
    Holland J, Agius M, Zaman R (2011) Prevalence of co-morbid bipolar disorder and migraine in a regional hospital psychiatric outpatient department. Psychiatr Danub 23(Suppl 1):S23–S24PubMedGoogle Scholar
  7. 7.
    D’Andrea G, Ostuzzi R, Francesconi F, Musco F, Bolner A, d’Onofrio F, Colavito D (2009) Migraine prevalence in eating disorders and pathophysiological correlations. Neurol Sci 30(Suppl 1):S55–S59PubMedCrossRefGoogle Scholar
  8. 8.
    Seidel S, Karwautz A, Wagner G, Zormann A, Eder H, Huemer J, Nattiashvili S, Wöber C, Wöber-Bingöl Ç (2011) Migraine in patients with eating disorders: a study using a sister-pair comparison design. Headache 51(2):220–225PubMedCrossRefGoogle Scholar
  9. 9.
    Modgill G, Jette N, Wang JL, Becker WJ, Patten SB (2011) A population-based longitudinal community study of major depression and migraine. Headache (Epub ahead of print)Google Scholar
  10. 10.
    Ratcliffe GE, Murray WE, Jacobi F, Belik SL, Sareen J (2009) The relationship between migraine and mental disorders in a population-based sample. Gen Hosp Psychiatry 31:14–19PubMedCrossRefGoogle Scholar
  11. 11.
    Mercante JPP, Peres MFP, Bernik MA (2011) Primary headaches in patients with generalized anxiety disorder. J Headache Pain 12:331–338PubMedCrossRefGoogle Scholar
  12. 12.
    Silberstein SD (2010) Association between restless legs syndrome and migraine. J Neurol Neurosurg Psychiatry 81:473–475PubMedCrossRefGoogle Scholar
  13. 13.
    Suzuki S, Suzuki K, Miyamoto M, Miyamoto T, Watanabe Y, Takashima R, Hirata K (2011) Evaluation of contributing factors to restless legs syndrome in migraine patients. J Neurol 258:2026–2035PubMedCrossRefGoogle Scholar
  14. 14.
    d’Onofrio F, Cologno D, Petretta V, Finocchi C, Autunno M, Marsala G, Usai S, Grazzi L, Omboni S, Fofi L, Barbanti P, Bussone G (2011) Restless legs syndrome is not associated with migraine with aura: a clinical study. Neurol Sci 32(Suppl 1):S153–S156PubMedCrossRefGoogle Scholar
  15. 15.
    Sancisi E, Cevoli S, Vignatelli L, Nicodemo M, Pierangeli G, Zanigni S, Grimaldi D, Cortelli P, Montagna P (2010) Increased prevalence of sleep disorders in chronic headache: a case–control study. Headache 50(9):1464–1472PubMedCrossRefGoogle Scholar
  16. 16.
    Brodtkorb E, Bakken IJ, Sjaastad O (2008) Comorbidity of migraine and epilepsy in a Norwegian community. Eur J Neurol 15:1421–1423PubMedCrossRefGoogle Scholar
  17. 17.
    Ottman R, Lipton RB, Ettinger AB, Cramer JA, Reed ML, Morrison A, Wan GJ (2011) Comorbidities of epilepsy: results from the Epilepsy Comorbidities and Health (EPIC) survey. Epilepsia 52(2):308–315PubMedGoogle Scholar
  18. 18.
    Schwedt T (2009) The migraine association with cardiac anomalies, cardiovascular disease and stroke. Neurol Clin 27(2):513–523PubMedCrossRefGoogle Scholar
  19. 19.
    Kurth T (2010) The association of migraine with ischemic stroke. Curr Neurol Neurosci Rep 10:133–139PubMedCrossRefGoogle Scholar
  20. 20.
    Bigal ME (2011) Migraine and cardiovascular disease. Arq Neuropsiquiatr 69(1):122–129PubMedGoogle Scholar
  21. 21.
    Rist PM, Tzourio C, Kurth T (2011) Association between lipid levels and migraine: cross-sectional analysis in the Epidemiology of Vascular Ageing Study. Cephalalgia 31:1459–1465PubMedCrossRefGoogle Scholar
  22. 22.
    Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T (2009) Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 339:b3914–b3925PubMedCrossRefGoogle Scholar
  23. 23.
    Kurth T, Chabriat H, Bousser MG (2012) Migraine and stroke: a complex association with clinical implications. Lancet Neurol 11:92–100PubMedCrossRefGoogle Scholar
  24. 24.
    Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M, Lipton RB (2010) Migraine and cardiovascular disease. Neurology 74:628–635PubMedCrossRefGoogle Scholar
  25. 25.
    Evans RW, de Tommaso M (2011) Migraine and fibromyalgia. Headache 51:195–299Google Scholar
  26. 26.
    Ravindran MK, Zheng Y, Timbol C, Merck SJ, Baraniuk JN (2011) Migraine headaches in Chronic Fatigue Syndrome (CFS): comparison of two prospective cross-sectional studies. BMC Neurol 11:30–39PubMedCrossRefGoogle Scholar
  27. 27.
    Riedl A, Schmidtmann M, Stengel A, Goebel M, Wisser AS, Klapp BF, Monnikes H (2008) Somatic comorbidities of irritable bowel syndrome: a systematic analysis. J Psychosom Res 64:573–582PubMedCrossRefGoogle Scholar
  28. 28.
    Tjensvoll AB, Harboe E, Gøransson LG, Beyer MK, Greve OJ, Herigstad A, Kvaløy JT, Omdal R (2011) Migraine is frequent in patients with systemic lupus erythematosus: a case–control study. Cephalalgia 31:401–408PubMedCrossRefGoogle Scholar
  29. 29.
    Katsiari CG, Vikelis M, Paraskevopoulou ES, Sfikakis PP, Mitsikostas DD (2011) Headache in systemic lupus erythematosus vs. multiple sclerosis: a prospective comparative study. Headache 51:1398–1407PubMedCrossRefGoogle Scholar
  30. 30.
    Lessa B, Santana A, Lima I, Almeida JM, Santiago M (2006) Prevalence and classification of headache in patients with systemic lupus erythematosus. Clin Rheumatol 25:850–853PubMedCrossRefGoogle Scholar
  31. 31.
    Tietjen GE, Bushnell CD, Herial NA, Utley C, White L, Hafeez F (2007) Endometriosis is associated with prevalence of comorbid conditions in migraine. Headache 47:1069–1078PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • G. Giannini
    • 1
    • 2
  • S. Cevoli
    • 1
    • 2
  • L. Sambati
    • 1
    • 2
  • P. Cortelli
    • 1
    • 2
  1. 1.IRCCS Institute of Neurological SciencesBolognaItaly
  2. 2.Department of Neurological SciencesAlma Mater Studiorum, University of BolognaBolognaItaly

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