Neurological Sciences

, Volume 34, Issue 4, pp 465–469 | Cite as

Increased axonal expression of nectin-1 in multiple sclerosis plaques

  • Karla J. Castellanos
  • Eva Gagyi
  • Bernadett Kormos
  • Klara Valyi-Nagy
  • Andras Voros
  • Deepak Shukla
  • Szatmar Horvath
  • Konstantin V. Slavin
  • Tibor Valyi-Nagy
Original Article
First Online:
Received:
Accepted:

Abstract

Nectin-1 is a cell adhesion molecule that plays a role in interneuronal synapse formation, in axonal guidance during development and possibly in neuron-glia interactions. To better understand axonal changes in MS, nectin-1 expression was determined by immunohistochemistry in normal adult human cerebral white matter (n = 4) and in six MS plaques (three active and three inactive). The intensity of axonal nectin-1 expression was scored on a scale of 0 to 4+. In normal adult cerebral white matter, axons showed weak nectin-1 expression with a score of 1.25 ± 0.50. Axonal nectin-1 expression was significantly stronger within both active (score = 3.33 ± 0.289, p = 0.001) and inactive (score = 2.16 ± 0.29, p = 0.038) MS plaques than in normal white matter. Axons in white matter adjacent to MS plaques showed nectin-1 expression (score = 1.5 ± 0.50) that was not statistically different from normal controls (p = 0.542). These findings raise the possibility that increased expression of nectin-1 in MS lesions plays a role in the pathogenesis of MS through participation in axonal responses to injury and mediation of altered neuron-glia interactions relevant to myelination.

Keywords

Nectin-1 Multiple sclerosis Axonal injury Axonal regeneration Myelination 
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Notes

Acknowledgments

These studies were supported by fellowship grants to E.G., B.K. and A.V. by the Rosztoczy Foundation.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Karla J. Castellanos
    • 1
  • Eva Gagyi
    • 1
  • Bernadett Kormos
    • 1
  • Klara Valyi-Nagy
    • 1
  • Andras Voros
    • 1
  • Deepak Shukla
    • 2
    • 3
  • Szatmar Horvath
    • 4
  • Konstantin V. Slavin
    • 5
  • Tibor Valyi-Nagy
    • 1
  1. 1.Departments of PathologyUniversity of Illinois at Chicago, College of MedicineChicagoUSA
  2. 2.Departments of Ophthalmology and Visual SciencesUniversity of Illinois at Chicago, College of MedicineChicagoUSA
  3. 3.Departments of Microbiology and ImmunologyUniversity of Illinois at Chicago, College of MedicineChicagoUSA
  4. 4.Department of PsychiatryVanderbilt UniversityNashvilleUSA
  5. 5.Departments of NeurosurgeryUniversity of Illinois at Chicago, College of MedicineChicagoUSA

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