Neurological Sciences

, Volume 34, Issue 4, pp 445–448 | Cite as

Cerebrospinal fluid cathepsin B and S

  • Elin Nilsson
  • Constantin Bodolea
  • Torsten Gordh
  • Anders Larsson
Original Article


Cathepsins are increased in the brain of elderly animals. We investigate the presence of cathepsin B and S in human cerebrospinal fluid (CSF) plasma and the associations with cystatin C, age and sex. We measured cathepsin B and S concentrations in CSFs from 118 persons, undergoing elective surgical procedures, with ELISA. Both cathepsin B and cathepsin S were positively correlated with age. No correlation was observed between cathepsin B or S and length, height or body mass index. Both cathepsin B and S were positively correlated to the cystatin C concentration in CSF. Calculated reference intervals were 4,893–17,636 pg/mL for cathepsin B and 2,681–11,459 pg/mL for cathepsin S. Elderly individuals had significantly higher levels of both cathepsin B (rs = 0.38, p = 0.00002) and cathepsin S (rs = 0.35, p = 0.0001) in CSF.


Cathepsin B Cathepsin S Cerebrospinal fluid Age 


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Elin Nilsson
    • 1
  • Constantin Bodolea
    • 2
  • Torsten Gordh
    • 3
  • Anders Larsson
    • 1
  1. 1.Department of Medical Sciences, Clinical Chemistry Uppsala University HospitalUppsalaSweden
  2. 2.Department of Anaesthesia and Intensive CareUniversity of Cluj NapocaCluj NapocaRomania
  3. 3.Department of Surgical SciencesUppsala University HospitalUppsalaSweden

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