Abstract
Movement disorders are common manifestations of human immunodeficiency virus (HIV) infection, and may sometimes be the initial manifestations of HIV infection. Although secondary progressive supranuclear palsy (PSP) due to factors such as paraneoplastic, vascular, and hypoxic-ischemic injury have been reported, PSP associated with HIV infection has received little attention. We describe a patient who displayed a progressive parkinsonian phenotype fulfilling the criteria for PSP over a period of a year. The parkinsonism was the initial manifestation of HIV infection and was eliminated by highly active antiretroviral therapy. This case report indicates that one should consider HIV infection as a cause of PSP-like parkinsonism.
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Tse W, Cersosimo MG, Gracies J-M, Morgello S, Olanow CW, Koller W (2004) Movement disorders and AIDS: a review. Parkinsonism Relat Disord 10(6):323–334
Cardoso F (2002) HIV-related movement disorders: epidemiology, pathogenesis and management. CNS Drugs 16(10):663–668
Mirsattari SM, Power C, Nath A (1998) Parkinsonism with HIV infection. Mov Disord 13(4):684–689
Litvan I, Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC, Goetz CG, Golbe LI, Grafman J, Growdon JH, Hallett M, Jankovic J, Quinn NP, Tolosa E, Zee DS (1996) Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 47(1):1–9
Kim HT, Shields S, Bhatia KP, Quinn N (2005) Progressive supranuclear palsy-like phenotype associated with bilateral hypoxic–ischemic striopallidal lesions. Mov Disord 20(6):755–757
Tan JH, Goh BC, Tambyah PA, Wilder-Smith E (2005) Paraneoplastic progressive supranuclear palsy syndrome in a patient with B-cell lymphoma. Parkinsonism Relat Disord 11(3):187–191
Koutsilieri E, Sopper S, Scheller C, ter Meulen V, Riederer P (2002) Parkinsonism in HIV dementia. J Neural Transm 109(5):767–775
Wenning GK, Litvan I, Tolosa E (2011) Milestones in atypical and secondary Parkinsonisms. Mov Disord 26(6):1083–1095
Bhidayasiri R, Riley DE, Somers JT, Lerner AJ, Büttner-Ennever JA, Leigh RJ (2001) Pathophysiology of slow vertical saccades in progressive supranuclear palsy. Neurology 57(11):2070–2077
Mwanza JC, Nyamabo LK, Tylleskär T, Plant GT (2004) Neuro-ophthalmological disorders in HIV infected subjects with neurological manifestations. Br J Ophthalmol 88(11):1455–1459
Khanlou N, Moore DJ, Chana G, Cherner M, Lazzaretto D, Dawes S, Grant I, Masliah E, Everall IP, HNRC group (2009) Increased frequency of α-synuclein in the substantia nigra in human immunodeficiency virus infection. J Neurovirol 15(2):131–138
Rosso AL, Mattos JP, Correa RB, Nicaretta DH, Novis SA (2009) Parkinsonism and AIDS: a clinical comparative study before and after HAART. Arquivos de Neuro-Psiquiatria 67(3B):827–830
Hersh BP, Rajendran PR, Battinelli D (2001) Parkinsonism as the presenting manifestation of HIV infection: improvement on HAART. Neurology 56(2):278–279
Kobylecki C, Silverdale MA, Varma A, Dick JP, Kellett MW (2009) HIV-associated parkinsonism with levodopa-induced dyskinesia and response to highly-active antiretroviral therapy. Mov Disord 24(16):2441–2442
Tisch S, Brew B (2009) Parkinsonism in HIV-infected patients on highly active antiretroviral therapy. Neurology 73(5):401–403
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This work was supported by a grant of the Korean Health Technology R&D Project, Ministry for Health Welfare & Family Affairs, Republic of Korea (A101712).
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Jang, W., Kim, JS., Ahn, J.Y. et al. Reversible progressive supranuclear palsy-like phenotype as an initial manifestation of HIV infection. Neurol Sci 33, 1169–1171 (2012). https://doi.org/10.1007/s10072-011-0875-y
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DOI: https://doi.org/10.1007/s10072-011-0875-y