Neurological Sciences

, Volume 33, Issue 3, pp 627–629 | Cite as

Cerebral venous and sinus thrombosis associated with subcutaneous immunoglobulin injection and oral contraceptive use

  • Jiangyong Min
  • Archit Bhatt
  • Rany Aburashed
  • Stephen Burton
Case Report


Although patients of cerebral sinus thrombosis after intravenous immunoglobulin (IVIG) has been previously reported; reports of cerebral venous thrombosis secondary to subcutaneous injection of immunoglobulin (SIG) in conjunction with oral contraceptives are nonexistent in the current literature. We describe here a patient of cerebral venous and sinus thrombosis occurring after the combination of SIG and oral contraceptive use. Furthermore, we shall explore proper clinical precautions for someone who receives IG therapy, especially in conjunction with the use of oral contraceptives.


Cerebral sinus thrombosis Subcutaneous injection of immunoglobulin (SIG) Oral contraceptives 


Conflict of interest

None declared.


  1. 1.
    Marie I, Maurey G, Herve F, Hellot MF, Levesque H (2006) Intravenous immunoglobulin-associated arterial and venous thrombosis: report of a series and review of the literature. Br J Dermatol 155:714–721PubMedCrossRefGoogle Scholar
  2. 2.
    Evangelou N, Littlewood T, Anslow P, Chapel H (2003) Transverse sinus thrombosis and IVIG treatment: a case report discussion of risk-benefit assessment for immunoglobulin treatment. J Clin Pathol 56:308–309PubMedCrossRefGoogle Scholar
  3. 3.
    Martinelli I, Sacchi E, Landi G, Taioli E, Duca F, Mannucci PM (1998) High risk of cerebral-vein thrombosis in carriers of a prothrombib-gene mutation and in users of oral contraceptives. N Engl J Med 338:1793–1799PubMedCrossRefGoogle Scholar
  4. 4.
    de Bruijn SF, Stam J, Vandenbroucke JP (1998) Increased risk of cerebral venous sinus thrombosis with third-generation oral contraceptives. Lancet 351:1404PubMedCrossRefGoogle Scholar
  5. 5.
    Bousser MG, Chiras J, Bories J, Castaigne P (1985) Cerebral venous thrombosis: a review of 38 cases. Stroke 16:199–213PubMedCrossRefGoogle Scholar
  6. 6.
    Wolberg AS, Kon RH, Monroe DM, Hoffman M (2000) Coagulation factor XI is a contaminant in intravenous immnoglobulin preparations. Am J Hematol 65:30–34PubMedCrossRefGoogle Scholar
  7. 7.
    Crouch ED, Watson LE (2002) Intravenous immunoglobulin-related acute coronary syndrome and coronary angiography in idiopathic thrombocytopenic purpura: a case report and literature review. Angiology 53:113–117PubMedCrossRefGoogle Scholar
  8. 8.
    Grillo JA, Gorson KC, Ropper AH, Lewis J, Weinstein R (2001) Rapid infusion of intravenous immune globulin in patients with neuromuscular disorders. Neurology 57:1699–1701PubMedCrossRefGoogle Scholar
  9. 9.
    Sherer Y, Levy Y, Langevitz P, Rauova L, Fabrizzi F, Shoenfeld Y (2001) Adverse effects of intravenous immunoglobulin therapy in 56 patients with autoimmune diseases. Pharmacology 62:133–137PubMedCrossRefGoogle Scholar
  10. 10.
    Vandenbroucke JP, Rosing J, Bloemenkamp KWM, Middeldorp S, Helmerhorst FM, Bouma BN, Rosendaal FR (2001) Oral contraceptives and the risk of venous thrombosis. New Eng J Med 344:1527–1535PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Jiangyong Min
    • 1
  • Archit Bhatt
    • 1
  • Rany Aburashed
    • 1
  • Stephen Burton
    • 1
  1. 1.Division of Cerebral Vascular Diseases, Sparrow Health System, Department of Neurology and OphthalmologyMichigan State UniversityEast LansingUSA

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