Neurological Sciences

, Volume 33, Issue 2, pp 343–345 | Cite as

Asymmetric chorea as presenting symptom in Graves’ disease

  • Jinsung Park
  • Jung-Guk Kim
  • Sung-Pa Park
  • Ho-Won LeeEmail author
Case Report


Chorea is an involuntary movement disorder characterized by irregular, brief movements that flow from one body part to another in a non-stereotyped fashion. In rare instances, chorea is associated with autoimmune thyroid disease. Most of them have been related with Hashimoto’s encephalopathy and few cases have been related with Graves’ disease. Most reported cases have been in women with Graves’ disease. We describe a 16-year-old male patient with asymmetric chorea as presenting symptom in Graves’ disease. He had no family history of neurological disease. Brain imaging, laboratory findings and electroencephalogram demonstrated no abnormality except for thyroid dysfunction which was proved by thyroid function test, sonography and radioiodine uptake scan. Asymmetric chorea improved over months after anti-thyroid medications. This asymmetry could be explained by difference in increased hypersensitivity or by the difference in the number of dopamine receptors, and an asymmetrical breakdown of blood–brain barrier due to their genetic differences.


Asymmetric Chorea Graves’ disease Male 

Supplementary material

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Jinsung Park
    • 1
  • Jung-Guk Kim
    • 2
  • Sung-Pa Park
    • 1
  • Ho-Won Lee
    • 1
    Email author
  1. 1.Department of Neurology, Brain Science and Engineering InstituteKyungpook National University School of MedicineDaeguSouth Korea
  2. 2.Department of Internal MedicineKyungpook National University School of MedicineDaeguSouth Korea

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