Neurological Sciences

, Volume 32, Issue 5, pp 819–824 | Cite as

Bone mineral density in ambulatory patients with multiple sclerosis

  • Chrissa Sioka
  • Stylianos Papakonstantinou
  • Andreas Fotopoulos
  • Yiannis Alamanos
  • Athanasia Georgiou
  • Sofia Tsouli
  • Sygliti-Henrietta Pelidou
  • Athanassios P. Kyritsis
  • John Kalef-Ezra
Original Article


Multiple sclerosis (MS) may be associated with reduced bone mass and higher frequency of osteoporosis. Femoral and spinal bone mineral density (BMD) in 70 ambulatory MS patients (46 females and 24 males) was compared with 100 sex-, age-, and BMI-matched control individuals. BMD was reduced in male patients (lumbar spine 0.976 ± 0.114 g/cm2 compared with 1.059 ± 0.147 g/cm2 in controls, p = 0.024, total hip 0.946 ± 0.136 g/cm2 compared to 1.036 ± 0.118 g/cm2 in controls, p = 0.008, femoral neck 0.812 ± 0.136 g/cm2 compared with 0.887 ± 0.135 g/cm2 in controls p = 0.042), and only in the total hip in female patients (0.88 ± 0.127 g/cm2 compared with 0.935 ± 0.112 g/cm2 in controls, p = 0.018). Multivariate analysis demonstrated that the predominantly affected site was the hip. MS patients exhibit increased frequency of low bone mass compared with controls. Further studies should assess the etiologic factors and employ appropriate therapies.


Osteoporosis Osteopenia Bone mineral density (BMD) Multiple sclerosis (MS) 


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Chrissa Sioka
    • 1
  • Stylianos Papakonstantinou
    • 2
    • 3
  • Andreas Fotopoulos
    • 1
  • Yiannis Alamanos
    • 4
  • Athanasia Georgiou
    • 1
  • Sofia Tsouli
    • 2
  • Sygliti-Henrietta Pelidou
    • 2
    • 3
  • Athanassios P. Kyritsis
    • 2
    • 3
  • John Kalef-Ezra
    • 5
  1. 1.Department of Nuclear MedicineUniversity Hospital of IoanninaIoanninaGreece
  2. 2.Department of NeurologyUniversity Hospital of IoanninaIoanninaGreece
  3. 3.Neurosurgical Research InstituteUniversity of IoanninaIoanninaGreece
  4. 4.Department of Public HealthUniversity of PatrasPatrasGreece
  5. 5.Department of Medical PhysicsUniversity Hospital of IoanninaIoanninaGreece

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