Neurological Sciences

, Volume 32, Issue 4, pp 609–613 | Cite as

Memantine attenuates the impairment of spatial learning and memory of pentylenetetrazol-kindled rats

  • Li-Jing Jia
  • Wei-Ping Wang
  • Zhou-Ping Li
  • Jun-Li Zhen
  • Li-Wei An
  • Rui-Sheng Duan
Original Article


Cognitive disorders after epilepsy can have a great impact on the quality of life of epileptic patients, though it has not drawn much attention. Even after identified, it is often undertreated or has gone untreated. Memantine has been approved to treat moderate to severe Alzheimer disease (AD), which is characterized by cognitive impairment. In present study, we determined the effects of memantine on PTZ-kindled rats, which can mimic the postseizure dysfunction that resembles symptoms observed in human epilepsy. We found that memantine can ameliorate the spatial learning and memory of epileptic rats. But contrary to previous claims that memantine can improve cognition in AD patients, without serious side effects on normal learning and memory abilities, we found that rats treated only with memantine exhibited the impaired spatial learning and memory ability. We conclude that memantine can improve cognition related to an excitotoxicity-induced pathologic state, but the potential side effects of memantine on the physiological processes should be considered.


Epilepsy Cognition Spatial learning and memory Kindling Memantine Pentylenetetrazol 


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Li-Jing Jia
    • 1
  • Wei-Ping Wang
    • 1
  • Zhou-Ping Li
    • 1
  • Jun-Li Zhen
    • 1
  • Li-Wei An
    • 1
  • Rui-Sheng Duan
    • 1
  1. 1.Department of NeurologyThe Second Hospital of Hebei Medical UniversityShijiazhuangPeople’s Republic of China

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